Evidence map›Paper›PMID 30609300›Full record

ArticleBrain and behavior2019

The Effect of sequential bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum level of BDNF and GABA in patients with primary insomnia.

Jie Feng, Qing Zhang, Chengliang Zhang, Zhongmin Wen, Xianju Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jie FengDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Qing ZhangLaboratory of Neurological, Department of Neurology, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Chengliang ZhangLaboratory of Neurological, Department of Neurology, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Zhongmin WenDepartment of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xianju ZhouLaboratory of Neurological, Department of Neurology, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.ORCID 0000-0003-1744-556X
Changzhou No.2 People's Hospital · CNSoochow University · CNTCM-Intigrated Cancer Center of Southern Medical University · CN

Funding

Core Violence and Injury Prevention Program (Core VIPP)U17CE002015 · CE · SOUTH CAROLINA DEPARTMENT OF PUBLIC HEALTH · PI SPIVEY, NICHOLE · 2011 to 2011
$250k
NCIPC CDC HHS U17 CE002015
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the effect of sequential bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex (DLPFC) on patients with primary insomnia (PI).

methodsA total of 32 eligible right-handed participants diagnosed by PI according to International classification of sleep disorders (ICD-3) were recruited into this study. Participants received 10 daily sessions of sequential bilateral 1 Hz rTMS over DLPFC. Before and after the whole procedure of rTMS, patients were assessed by Pittsburgh Sleep Quality Index (PSQI) for the severity of sleep disturbance. Meanwhile, serum concentration of brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) in patients was measured by ELISA and UPLC, respectively. Moreover, the amplitude of MEPs reflecting the right cortical excitability was examined. Finally, Pearson correlation analysis was performed to evaluate the correlation among the change of these variables.

resultsAfter rTMS treatment, the PSQI score was markedly decreased as compared to pre-rTMS; the concentrations of serum BDNF and GABA were significantly higher; the amplitude of MEPs was markedly reduced. Pearson correlation analysis revealed that the change of PSQI score was negatively associated with the alteration of serum BDNF level and serum GABA level, and positively associated with the change of MEPs amplitude; the change of MEPs amplitude was negatively associated with fold change in the serum BDNF level and the serum GABA level; the increase in serum GABA level was positively associated with the serum BDNF level.

conclusionsA sequential bilateral low-frequency rTMS over DLPFC significantly improves primary insomnia probably by increasing the level of BDNF and GABA in the brain and reducing cortical excitability.

Indexed as

Sleep Initiation and Maintenance DisordersAdultBrain-Derived Neurotrophic FactorCorrelation of DataFemalegamma-Aminobutyric AcidHumansMaleMiddle AgedPrefrontal CortexTranscranial Magnetic StimulationTreatment OutcomeBrain-Derived Neurotrophic Factorgamma-Aminobutyric Acidbrain-derived neurotrophic factorprimary insomniarepetitive transcranial magnetic stimulationγ-aminobutyric acid

Identifiers

PMID30609300
PMCPMC6379591
OpenAlexW2907361360

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.