Evidence map›Paper›PMID 30609058›Full record

ArticleMedical physics2019

Body region localization in whole-body low-dose CT images of PET/CT scans using virtual landmarks.

Peirui Bai, Jayaram K Udupa, Yubing Tong, ShiPeng Xie, Drew A Torigian

Abstract read
In one paragraph

Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peirui BaiCollege of Electronics, Communication and Physics, Shandong University of Science and Technology, Qingdao, Shandong, 266590, China.
Jayaram K UdupaMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yubing TongMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
ShiPeng XieMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Drew A TorigianMedical Image Processing Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Funding

Automated Object Contouring Methods & Software for Radiotherapy PlanningR42CA199735 · NCI · QUANTITATIVE RADIOLOGY SOLUTIONS, LLC · PI OWENS, STEVE, UDUPA, JAYARAM K · 2018 to 2020
$1.9M
Automated Object Contouring Methods & Software for Thoracic Radiotherapy PlanningR41CA199735 · NCI · QUANTITATIVE RADIOLOGY SOLUTIONS, LLC · PI UDUPA, JAYARAM K · 2016 to 2016
$254k
National Natural Science Foundation of China 61471225NCI NIH HHS R41 CA199735NCI NIH HHS R42 CA199735NIH HHS 1R41CA199735-01A1
6 · The paper itself

Abstract

purposeRadiological imaging and image interpretation for clinical decision making are mostly specific to each body region such as head and neck, thorax, abdomen, pelvis, and extremities. In this study, we present a new solution to trim automatically the given axial image stack into image volumes satisfying the given body region definition.

methodsThe proposed approach consists of the following steps. First, a set of reference objects is selected and roughly segmented. Virtual landmarks (VLs) for the objects are then identified by using principal component analysis and recursive subdivision of the object via the principal axes system. The VLs can be defined based on just the binary objects or objects with gray values also considered. The VLs may lie anywhere with respect to the object, inside or outside, and rarely on the object surface, and are tethered to the object. Second, a classic neural network regressor is configured to learn the geometric mapping relationship between the VLs and the boundary locations of each body region. The trained network is then used to predict the locations of the body region boundaries. In this study, we focus on three body regions - thorax, abdomen, and pelvis, and predict their superior and inferior axial locations denoted by TS(I), TI(I), AS(I), AI(I), PS(I), and PI(I), respectively, for any given volume image I. Two kinds of reference objects - the skeleton and the lungs and airways, are employed to test the localization performance of the proposed approach.

resultsOur method is tested by using low-dose unenhanced computed tomography (CT) images of 180 near whole-body

conclusionsPrecise body region identification automatically in whole-body or body region tomographic images is vital for numerous medical image analysis and analytics applications. Despite its importance, this issue has received very little attention in the literature. We present a solution to this problem in this study using the concept of virtual landmarks. The method achieves localization accuracy within 2-3 slices, which is roughly comparable to the variation found in localization by experts. As long as the reference objects can be roughly segmented, the method with its learned VLs-to-boundary location relationship and predictive ability is transferable from one image modality to another.

Indexed as

AlgorithmsDiseaseRadiography, ThoracicAbdomenAnatomic LandmarksCase-Control StudiesHumansImage Processing, Computer-AssistedModels, StatisticalPelvisPositron Emission Tomography Computed TomographyWhole Body Imagingbody region identificationcomputed tomography (CT)neural network learningprincipal component analysisvirtual landmarks

Identifiers

PMID30609058
PMCPMC6416059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.