ArticlePLoS pathogens2019
Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed, 139 citations in OpenAlex.
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- Reduced MGE burden, virulence optimization, and acid stress tolerance shape the clonal succession of MRSA ST59.Science advances · 2026Article
- New cerebrosides from the polar starfish Leptasterias polaris acervata and their cardioprotective and anti-inflammatory activity.Journal of natural medicines · 2026Article
- Small-colony variants of Staphylococcus aureus: hidden threat in chronic and recurrent infections.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Effect of metabolites on the survival and biofilm formation of Pantoea piersonii (Basionym: Kalamiella piersonii) in synthetic urine media.BMC microbiology · 2026Article
- Insights into the dynamic cell associated and secreted proteome of Staphylococcus aureus cultured in TSB and milk media: a proteomic analysis.BMC microbiology · 2025Article
- ArgT functions as an arginine transporter inJournal of bacteriology · 2025Article
- Unraveling proteomic chaos by independent component analysis-ClpX proficiency promotes the iron and oxygen limitation responses ofmSystems · 2025Article
- Urease promotes pH homeostasis and growth ofJournal of bacteriology · 2025Article
- Inhibitory Effect of Amentoflavone on the Virulence of MRSA by Targeting ClpP.Journal of cellular and molecular medicine · 2025Article
- Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence.Medical microbiology and immunology · 2025Article
- Comparative proteomics analysis of MRSA under different experimental conditions.Scientific reports · 2025Article
- Revisiting nitrogen assimilation strategies in the mammalian gut: lessons from Enterobacteriaceae as pathobiont models and a challenge to the limitation paradigm.Archives of microbiology · 2025Review
- sRNA-mediated crosstalk between cell wall stress and galactose metabolism in Staphylococcus aureus.Nucleic acids research · 2025Article
- Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms.FEBS letters · 2025Review
- TEAL-Seq: targeted expression analysis sequencing.mSphere · 2025Article
- Global changes inInfection and immunity · 2025Article
16 more citing papers are in PubMed but not listed here.
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10 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus causes acute and chronic infections resulting in significant morbidity. Urease, an enzyme that generates NH3 and CO2 from urea, is key to pH homeostasis in bacterial pathogens under acidic stress and nitrogen limitation. However, the function of urease in S. aureus niche colonization and nitrogen metabolism has not been extensively studied. We discovered that urease is essential for pH homeostasis and viability in urea-rich environments under weak acid stress. The regulation of urease transcription by CcpA, Agr, and CodY was identified in this study, implying a complex network that controls urease expression in response to changes in metabolic flux. In addition, it was determined that the endogenous urea derived from arginine is not a significant contributor to the intracellular nitrogen pool in non-acidic conditions. Furthermore, we found that during a murine chronic renal infection, urease facilitates S. aureus persistence by promoting bacterial fitness in the low-pH, urea-rich kidney. Overall, our study establishes that urease in S. aureus is not only a primary component of the acid response network but also an important factor required for persistent murine renal infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.