Observational studyCritical care medicine2019
Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study).
Observational study in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Biomarkers in Blood and Tissue Samples of Septic Patients Complicated With Gastrointestinal Dysfunction
The HYPA Study: Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients Undergoing Open and Robotic Pancreatic Procedures
Prognostic Value of Continuous Intra-abdominal Pressure (CIAP) and Continuous Abdominal Perfusion Pressure (CAPP) Monitoring for Acute Kidney Injury (AKI) Prediuction in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
Expert Consensus On Definitions And Management Of Intra-Abdominal Hypertension And Abdominal Compartment Syndrome
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Systematic Review of Diagnostic Sensors for Intra-Abdominal Pressure Monitoring.Sensors (Basel, Switzerland) · 2021Pooled it
- Intra-abdominal hypertension and increased acute kidney injury risk: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- Clinical validation of an intra-abdominal pressure monitoring system by comparison with pneumoperitoneum pressure.Journal of clinical monitoring and computing · 2026Article
- Association of Serial Intra-Abdominal Pressure Measurements with Renal Outcomes and Mortality in Critically Ill Adults.Journal of clinical medicine · 2026Article
- Clinical characteristics and prognostic factors of severe intra-abdominal infection due to gastrointestinal perforation: a retrospective cohort study.BMC surgery · 2026Article
- Feasibility and early experience with venous Doppler congestion assessment in post-operative lung transplant patients.The ultrasound journal · 2026Article
- SOFA score combined with heart rate variability predicts in-hospital mortality in patients with intra-abdominal hypertension: a retrospective study.BMC medical informatics and decision making · 2026Article
- Incidence of intra-abdominal hypertension after liver transplantation with temporary portocaval shunt - A prospective cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Radiologic evaluation of abdominal compartment syndrome: an updated educational review.Abdominal radiology (New York) · 2026Review
- Abdominal compartment syndrome after robotic-assisted thoracoscopic surgery (RATS) diaphragm plication.Journal of surgical case reports · 2026Article
- Acute kidney injury is a major mediator of intra-abdominal pressure-related mortality in critically ill patients: a longitudinal analysis.Journal of anesthesia, analgesia and critical care · 2026Article
- Assessment of the impact of furosemide use on outcomes in patients with intra-abdominal hypertension: a retrospective cohort study from the MIMIC-IV database.BMC gastroenterology · 2026Article
- Development of a nomogram prediction model for postoperative intra-abdominal hypertension in patients with intra-abdominal infection sepsis based on analgesic drug selection.Frontiers in surgery · 2026Article
- Early risk prediction model for intra-abdominal hypertension in adult ICU patients: a prospective cohort study.Frontiers in medicine · 2026Article
- Renal congestion syndrome in critically ill patients: a neglected mechanism of acute kidney injury - A narrative review.Annals of intensive care · 2026Review
- Application of electrical impedance tomography-guided PEEP titration in acute respiratory distress syndrome patients with intra-abdominal hypertension.World journal of emergency medicine · 2026Article
- Right Atrial Pressure Estimation Using Point-of-Care Ultrasound of the Superior Vena Cava in the Cardiovascular Intensive Care Unit: A Case Series.CASE (Philadelphia, Pa.) · 2025Article
- Gastrointestinal complications in intensive care.Medical review (2021) · 2025Review
- Observational
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
objectivesTo identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population.
designProspective observational study.
settingFifteen ICUs worldwide. PATIENTS: Consecutive adult ICU patients with a bladder catheter.
interventionsNone. MEASUREMENTS AND MAIN
resultsFour hundred ninety-one patients were included. Intra-abdominal pressure was measured a minimum of every 8 hours. Subjects with a mean intra-abdominal pressure equal to or greater than 12 mm Hg were defined as having intra-abdominal hypertension. Intra-abdominal hypertension was present in 34.0% of the patients on the day of ICU admission (159/467) and in 48.9% of the patients (240/491) during the observation period. The severity of intra-abdominal hypertension was as follows: grade I, 47.5%; grade II, 36.6%; grade III, 11.7%; and grade IV, 4.2%. The severity of intra-abdominal hypertension during the first 2 weeks of the ICU stay was identified as an independent predictor of 28- and 90-day mortality, whereas the presence of intra-abdominal hypertension on the day of ICU admission did not predict mortality. Body mass index, Acute Physiology and Chronic Health Evaluation II score greater than or equal to 18, presence of abdominal distension, absence of bowel sounds, and positive end-expiratory pressure greater than or equal to 7 cm H2O were independently associated with the development of intra-abdominal hypertension at any time during the observation period. In subjects without intra-abdominal hypertension on day 1, body mass index combined with daily positive fluid balance and positive end-expiratory pressure greater than or equal to 7 cm H2O (as documented on the day before intra-abdominal hypertension occurred) were associated with the development of intra-abdominal hypertension during the first week in the ICU.
conclusionsIn our mixed ICU patient cohort, intra-abdominal hypertension occurred in almost half of all subjects and was twice as prevalent in mechanically ventilated patients as in spontaneously breathing patients. Presence and severity of intra-abdominal hypertension during the observation period significantly and independently increased 28- and 90-day mortality. Five admission day variables were independently associated with the presence or development of intra-abdominal hypertension. Positive fluid balance was associated with the development of intra-abdominal hypertension after day 1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.