ArticleJournal of the American Heart Association2018
Association of Blood Pressure and Arterial Stiffness With Cognition in 2 Population-Based Child and Adult Cohorts.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Knowledge gaps and future directions in cognitive functions in children and adolescents with primary arterial hypertension: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Arterial Stiffness and Cognition Among Adults: A Systematic Review and Meta-Analysis of Observational and Longitudinal Studies.Journal of the American Heart Association · 2020Pooled it
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Interaction between obesity and asthma in children and adolescents with hypertension based on NHANES 2007-2020.Frontiers in public health · 2025Article
- Association between arterial health and cognition in adolescents: The PANIC study.Physiological reports · 2024Article
- Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age.Journal of the American Heart Association · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Associations of physical fitness with cortical inhibition and excitation in adolescents and young adults.Frontiers in neuroscience · 2024Article
- Evaluation of school achievements in adolescents with primary hypertension.Northern clinics of Istanbul · 2024Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- The Triglyceride-Glucose Index Is Associated with Longitudinal Cognitive Decline in a Middle-Aged to Elderly Population: A Cohort Study.Journal of clinical medicine · 2022Article
- Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.JCI insight · 2022Article
- Pulsatile tympanic membrane displacement is associated with cognitive score in healthy subjects.Cerebral circulation - cognition and behavior · 2022Article
- Body fat, cardiovascular risk factors and brain structure in school-age children.International journal of obesity (2005) · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Associations of cardiorespiratory fitness, adiposity, and arterial stiffness with cognition in youth.Physiological reports · 2020Article
- The association between resting-state functional magnetic resonance imaging and aortic pulse-wave velocity in healthy adults.Human brain mapping · 2020Article
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- Vascular Aging and Disease of the Small Vessels.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Blood Pressure and Cognitive Function in Children and Adolescents.Hypertension (Dallas, Tex. : 1979) · 2019Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Background High blood pressure levels and higher arterial stiffness have been shown to be associated with lower cognition during adulthood, possibly by accumulative changes over time. However, vascular factors may already affect the brain during early life. Methods and Results We examined the relation between cognition and vascular factors within 5853 children from the Generation R Study (mean age 6.2 years) and 5187 adults from the Rotterdam Study (mean age 61.8 years). Diastolic and systolic blood pressure and arterial stiffness were assessed, the latter by measuring pulse-wave velocity and pulse pressure. For cognition, the Generation R Study relied on nonverbal intelligence, whereas the Rotterdam Study relied on a cognitive test battery to calculate the g-factor, a measure of global cognition. In the Generation R Study, standardized diastolic blood pressure showed a significant association with standardized nonverbal intelligence (β=-0.030, 95% confidence interval=[-0.054; -0.005]) after full adjustment. This association held up after excluding the top diastolic blood pressure decile (β=-0.042 [-0.075; -0.009]), suggesting that the relation holds in normotensives. Within the Rotterdam Study, standardized cognition associated linearly with standardized systolic blood pressure (β=-0.036 [-0.060; -0.012]), standardized pulse-wave velocity (β=-0.064 [-0.095; -0.033]), and standardized pulse pressure (β=-0.044 [-0.069; -0.020], and nonlinearly with standardized diastolic blood pressure (quadratic term β=-0.032 [-0.049; -0.015]) after full adjustment. Conclusions Blood pressure and cognition may already be related in the general population during early childhood, albeit differently than during adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.