ArticleThe Journal of organic chemistry2019
Synthesis of ( R)- and ( S)-Fmoc-Protected Diethylene Glycol Gamma PNA Monomers with High Optical Purity.
Article in The Journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid.Cell reports. Physical science · 2023Article
- Walking through the wonder years of artificial DNA: peptide nucleic acid.Molecular biology reports · 2020Review
- Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor.Bioorganic & medicinal chemistry · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A robust synthetic route has been developed for preparing optically pure, Fmoc-protected diethylene glycol-containing ( R)- and ( S)-γPNA monomers. The strategy involves the application of 9-(4-bromophenyl)-9-fluorenyl as a temporary, safety-catch protecting group for the suppression of epimerization in the O-alkylation and reductive amination steps. The optical purities of the final monomers were determined to be greater than 99.5% ee, as assessed by
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Registered trials
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