Evidence map›Paper›PMID 30608051›Full record

SynthesisThe American journal of tropical medicine and hygiene2019

Mass Azithromycin Distribution to Prevent Childhood Mortality: A Pooled Analysis of Cluster-Randomized Trials.

Catherine E Oldenburg, Ahmed M Arzika, Abdou Amza, Teshome Gebre, Khumbo Kalua, Zakayo Mrango, Sun Y Cotter, Sheila K West, Robin L Bailey, Paul M Emerson and 4 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  19. World Pneumonia Day during a global pneumonia pandemic: 12 November 2020.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  20. Effect Modification by Baseline Mortality in the MORDOR Azithromycin Trial.The American journal of tropical medicine and hygiene · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 6 countries.

Catherine E OldenburgDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Ahmed M ArzikaThe Carter Center, Niamey, Niger.
Abdou AmzaProgramme FSS/Université Abdou Moumouni de Niamey, Programme National de Santé Oculaire, Niamey, Niger.
Teshome GebreThe Carter Center, Addis Ababa, Ethiopia.
Khumbo KaluaBlantyre Institute for Community Outreach and the College of Medicine, University of Malawi, Blantyre, Malawi.
Zakayo MrangoNational Institute for Medical Research, Dar es Salaam, Tanzania.
Sun Y CotterFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, California.
Sheila K WestThe Dana Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Robin L BaileyThe London School of Tropical Hygiene and Medicine, London, United Kingdom.
Paul M EmersonThe International Trachoma Initiative, Decatur and Emory University, Atlanta, Georgia.
Kieran S O'BrienFrancis I Proctor Foundation, University of California, San Francisco, San Francisco, California.
Travis C PorcoDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Jeremy D KeenanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
Thomas M LietmanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California.
San Francisco Foundation · USUniversity of California, San Francisco · USAbdou Moumouni University · NEInternational Trachoma Initiative · USJohns Hopkins University · USLondon School of Hygiene & Tropical Medicine · GBNational Institute for Medical Research · TZThe Carter Center · ETUnited Nations Children's Fund Niger · NEUniversity of Malawi · MW

Funding

TANA IIU10EY016214 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIETMAN, THOMAS M · 2004 to 2013
$4.4M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NEI NIH HHS U10 EY016214NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

Mass drug administration (MDA) with azithromycin may reduce under-5 child mortality (U5M) in sub-Saharan Africa. Here, we conducted a pooled analysis of all published cluster-randomized trials evaluating the effect of azithromycin MDA on child mortality. We pooled data from cluster-randomized trials randomizing communities to azithromycin MDA versus control. We calculated mortality rates in the azithromycin and control arms in each study, and by country for multisite studies including multiple countries. We conducted a two-stage individual community data meta-analysis to estimate the effect of azithromycin for prevention of child mortality. Three randomized controlled trials in four countries (Ethiopia, Malawi, Niger, and Tanzania) were identified. The overall pooled mortality rate was 15.9 per 1,000 person-years (95% confidence interval [CI]: 15.5-16.3). The pooled mortality rate was lower in azithromycin-treated communities than in placebo-treated communities (14.7 deaths per 1,000 person-years, 95% CI: 14.2-15.3 versus 17.2 deaths per 1,000 person-years, 95% CI: 16.5-17.8). There was a 14.4% reduction in all-cause child mortality in communities receiving azithromycin MDA (95% CI: 6.3-21.7% reduction,

Indexed as

Child MortalityInfant MortalityMass Drug AdministrationAdministration, OralAnti-Bacterial AgentsAzithromycinChild, PreschoolCommunicable Disease ControlCommunicable DiseasesHumansInfantAnti-Bacterial AgentsAzithromycin

Identifiers

PMID30608051
PMCPMC6402901
OpenAlexW2907115580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.