Evidence map›Paper›PMID 30607809›Full record

Trial reportThe patient2019

EQ-5D-5L is More Responsive than EQ-5D-3L to Treatment Benefit of Cataract Surgery.

Mihir Gandhi, Marcus Ang, Kelvin Teo, Chee Wai Wong, Yvonne Chung-Hsi Wei, Rachel Lee-Yin Tan, Mathieu F Janssen, Nan Luo

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The patient, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Psychometric properties of the EQ-5D-5L: a systematic review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
  2. Pooled it
  3. Sensitivity to change of generic preference-based instruments (EQ-5D-3L, EQ-5D-5L, and HUI3) in the context of treatment for people with prescription-type opioid use disorder in Canada.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Trial
  4. Trial
  5. Assessing Quality of life of Patients with Cataract and Glaucoma using Generic and Vision-Specific Instruments in India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Comparison of EQ-5D-3L and 5L versions following operative fixation of closed ankle fractures.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  12. Validation and comparison of five preference-based measures among age-related macular degeneration patients: evidence from mainland China.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  13. Article
  14. Article
  15. Validity of the EQ-5D-5L questionnaire among the general population of Poland.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Article
  16. Observational
  17. Assessing the construct validity and responsiveness of Preference-Based Measures (PBMs) in cataract surgery patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Article
  18. A vision 'bolt-on' increases the responsiveness of EQ-5D: preliminary evidence from a study of cataract surgery.The European journal of health economics : HEPAC : health economics in prevention and care · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mihir GandhiDepartment of Biostatistics, Singapore Clinical Research Institute, Singapore, Singapore.ORCID 0000-0002-8902-2710
Marcus AngCorneal and External Eye Disease Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore. Marcus.Ang@Singhealth.com.sg.
Kelvin TeoCorneal and External Eye Disease Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore.
Chee Wai WongCorneal and External Eye Disease Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore.
Yvonne Chung-Hsi WeiCorneal and External Eye Disease Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, Singapore.
Rachel Lee-Yin TanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Mathieu F JanssenSection Medical Psychology and Psychotherapy, Department of Psychiatry, Erasmus MC, Rotterdam, Netherlands.
Nan LuoSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is not clear whether 5-level EQ-5D (EQ-5D-5L) utilities based on recently developed value sets are more responsive than 3-level EQ-5D (EQ-5D-3L) utilities.

objectivesThe study aims were to compare (1) the responsiveness of EQ-5D-5L and EQ-5D-3L utilities and (2) the responsiveness of these utilities with the Short Form-6 Dimension (SF-6D) and Health Utilities Index Mark 3 (HUI3) utilities to the treatment benefit of cataract surgery.

methodsA total of 148 patients were interviewed before and after their cataract surgery using EQ-5D-3L, EQ-5D-5L, SF-6D, and HUI3. Responsiveness was assessed for all measures using the mean change (post-treatment-pre-treatment), standardized effect size (SES), standardized response mean (SRM), and F-statistic.

resultsUsing the Singapore value sets, mean change for EQ-5D-3L and EQ-5D-5L utilities was 0.016 and 0.028, SES was 0.097 and 0.199; SRM was 0.091 and 0.196; and F-statistic was 1.2 and 5.7, respectively. Similar trends were observed using the UK/England EQ-5D value sets, although the magnitude was slightly smaller. The mean change, SES, SRM and F-statistics for SF-6D (UK value set) were 0.020, 0.234, 0.249, and 9.2, respectively. The values of mean change, SES, SRM and F-statistics for HUI3 (Canada value set) were 0.080, 0.472, 0.474, and 33.3, respectively.

conclusionsThe EQ-5D-5L utilities tend to be more responsive than the EQ-5D-3L utilities to treatment benefits of cataract surgery. The HUI3 utilities are more responsive than both the EQ-5D-5L and SF-6D, and SF-6D utilities may be slightly more responsive than the EQ-5D-5L for assessing patients undergoing cataract surgery.

Indexed as

AgedCataract ExtractionCost-Benefit AnalysisFemaleHealth StatusHumansInterviews as TopicLongitudinal StudiesMaleMiddle AgedPatient PreferenceProspective StudiesPsychometricsQuality of LifeReproducibility of ResultsSingapore

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.