Evidence map›Paper›PMID 30607799›Full record

ArticleJournal of cardiovascular translational research2019

lncRNA HOTAIR Protects Myocardial Infarction Rat by Sponging miR-519d-3p.

Dongying Zhang, Bingjian Wang, Min Ma, Kun Yu, Qing Zhang, Xiwen Zhang

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. lncRNA HOTAIR and Cardiovascular diseases.Functional & integrative genomics · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Association betweenJournal of personalized medicine · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Long Noncoding RNAs in Myocardial Ischemia-Reperfusion Injury.Oxidative medicine and cellular longevity · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dongying ZhangDepartment of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.
Bingjian WangDepartment of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.
Min MaDepartment of Cardiology, The Sixth People's Hospital of Chengdu, No. 16 South Jianshe Street, Chengdu, 610051, Sichuan, China.
Kun YuDepartment of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.
Qing ZhangDepartment of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.
Xiwen ZhangDepartment of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China. ym189003@163.com.
Huaian First People’s Hospital · CNNanjing Medical University · CNThe Sixth People's Hospital of Shenyang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. In this study, we focused on exploring the roles and underlying regulatory mechanisms of Hox transcript antisense intergenic RNA (HOTAIR) and miR-519d-3p in myocardial infarction. To comprehensively understand the role of microRNA in MI rat, we construct MI rat model by permanent ligation of the left anterior descending (LAD) coronary artery. Cardiac troponin I and creatine kinase-MB concentration measured by ELISA and infract size of heart section analyzed by TTC staining were served as evaluation indicators to confirmed the established model. Based on the bioinformatics assay and qRT-PCR, we found that the expression of miR-519d-3p was upregulated remarkably. Dual-luciferase reporter assays were performed to investigate the interaction of lncRNA HOTAIR and miR-519d-3p. In order to investigate the potential mechanism of lncRNA HOTAIR and miR-519d-3p, flow cytometry was applied to measure apoptotic cardiomyocytes and western blot was used to detect expressions of apoptotic related protein Bax, Bcl-2, and caspase-3 in cardiomyocytes in vitro and myocardial infraction in vivo. Downregulating miR-519d-3p or overexpressing HOTAIR alleviated MI or hypoxia-induced cardiomyocytes apoptosis. Taken together, our results showed that the interaction of miR-519d-3p and HOTAIR can protect MI and hypoxia-induced cardiomyocytes apoptosis, providing the potential therapeutic target for MI treatment.

Indexed as

ApoptosisAnimalsbcl-2-Associated X ProteinCaspase 3Cell HypoxiaCell LineDisease Models, AnimalGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMaleMicroRNAsMyocardial InfarctionMyocytes, CardiacNeovascularization, PhysiologicProto-Oncogene Proteins c-bcl-2Bax protein, ratbcl-2-Associated X ProteinBcl2 protein, ratCasp3 protein, ratCaspase 3HOTAIR long untranslated RNA, ratMicroRNAsProto-Oncogene Proteins c-bcl-2RNA, Long NoncodingCardiomyocytes apoptosisCoronary heart diseaseHOTAIRmiR-519d-3pMyocardial infarction

Identifiers

PMID30607799
OpenAlexW2906749463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.