Evidence map›Paper›PMID 30607797›Full record

ReviewCerebellum (London, England)2019

Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?

Jan Cendelin, Annalisa Buffo, Hirokazu Hirai, Lorenzo Magrassi, Hiroshi Mitoma, Rachel Sherrard, Frantisek Vozeh, Mario Manto

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 5 countries.

Jan CendelinDepartment of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzen, Czech Republic.
Annalisa BuffoDepartment of Neuroscience Rita Levi-Montalcini, University of Turin, 10126, Turin, Italy.
Hirokazu HiraiDepartment of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, 3-39-22, Maebashi, Gunma, 371-8511, Japan.
Lorenzo MagrassiNeurosurgery, Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Fondazione IRCCS Policlinico S. Matteo, Università degli Studi di Pavia, 27100, Pavia, Italy.
Hiroshi MitomaMedical Education Promotion Center, Tokyo Medical University, Tokyo, Japan.
Rachel SherrardIBPS, UMR8256 Biological Adaptation and Ageing, Sorbonne Université and CNRS, Paris, France.
Frantisek VozehDepartment of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzen, Czech Republic.
Mario MantoDepartment of Neurology, CHU-Charleroi, 6000, Charleroi, Belgium. mmanto@ulb.ac.be.
Charles University · CZGrand Charleroi Hospital · BEGunma University · JPSorbonne Université · FRTokyo Medical University · JPUniversity of Pavia · ITUniversity of Turin · IT

Funding

Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas (BR) Q39Funds of the University of Turin and of Ministero dell'Istruzione, dell'Università e della Ricerca --Gunma University Initiative for Advanced Research --Ministerstvo Školství, Mládeže a Tělovýchovy (CZ) LO1503
6 · The paper itself

Abstract

Restoration of damaged central nervous system structures, functional recovery, and prevention of neuronal loss during neurodegenerative diseases are major objectives in cerebellar research. The highly organized anatomical structure of the cerebellum with numerous inputs/outputs, the complexity of cerebellar functions, and the large spectrum of cerebellar ataxias render therapies of cerebellar disorders highly challenging. There are currently several therapeutic approaches including motor rehabilitation, neuroprotective drugs, non-invasive cerebellar stimulation, molecularly based therapy targeting pathogenesis of the disease, and neurotransplantation. We discuss the goals and possible beneficial mechanisms of transplantation therapy for cerebellar damage and its limitations and factors determining outcome.

Indexed as

AnimalsCell- and Tissue-Based TherapyCerebellar DiseasesAtaxiasCerebellar reserveCerebellumNeurotransplantationStem cells

Identifiers

PMID30607797
OpenAlexW2907121928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.