Evidence map›Paper›PMID 30607731›Full record

ArticleDoklady. Biochemistry and biophysics2018

The Antitumor Efficacy of a Complex Based on Two-Vector System for Coexpression of the Suicide Gene Fcu1 and Cre Recombinase.

O A Bezborodova, I V Alekseenko, E R Nemtsova, A A Pankratov, O B Filyukova, R I Yakubovskaya, M B Kostina, V K Potapov, E D Sverdlov

Abstract read
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Article in Doklady. Biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

O A BezborodovaMoscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia. olgabezborodova@yandex.ru.
I V AlekseenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
E R NemtsovaMoscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
A A PankratovMoscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
O B FilyukovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
R I YakubovskayaMoscow Cancer Research Institute, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, 125284, Russia.
M B KostinaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
V K PotapovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
E D SverdlovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we evaluated the antitumor activity of a gene therapy complex in which the tumor-specific control of the expression of the effector suicide gene FCU1 was performed using a two-vector system based on the site-specific Cre-LoxP recombinase system. The complex of interest showed a high therapeutic potential in a mouse colon adenocarcinoma model.

Indexed as

AdenocarcinomaColonic NeoplasmsGenes, Transgenic, SuicideGenetic VectorsIntegrasesNeoplasms, ExperimentalAnimalsCell Line, TumorMice, Inbred BALB CCre recombinaseIntegrases

Identifiers

PMID30607731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.