ArticleLasers in medical science2019
Variable heat shock response model for medical laser procedures.
Article in Lasers in medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Photothermal interaction of a 1927 nm Thulium laser with MatriDerm: an in vitro study.Lasers in medical science · 2026Article
- Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review.International journal of dermatology · 2026Article
- Ex vivo and computational investigation of corneal iontophoresis to enhance penetration of high-molecular-weight compounds: a study using albumin as a model molecule.Scientific reports · 2026Article
- Alterations in scalp microorganisms after Er: YAG laser treatment for Shanghai androgenetic alopecia patients.Lasers in medical science · 2025Article
- The Impact of IncontiLase Er:YAG Laser Treatment on the Quality of Life of Women With Stress Urinary Incontinence.Advances in urology · 2025Article
- Synergistic Effects of Thread Lifting, Autologous Fat Grafting, and Multi-Modal Laser Therapy in Facial Rejuvenation.Aesthetic surgery journal. Open forum · 2025Article
- Review
- Vaginal Laser Treatment for the Genitourinary Syndrome of Menopause in Breast Cancer Survivors: A Narrative Review.Cureus · 2023Review
- Long-Term Improvement in Urinary Incontinence in an Elite Female Athlete Through the Laser Treatment: A Case Report.Cureus · 2023Article
- Non-ablative Er:YAG laser is an effective tool in the treatment arsenal of androgenetic alopecia.Journal of cosmetic dermatology · 2022Article
- Periocular rejuvenation using a unique non-ablative long-pulse 2940 nm Er:YAG laser.Lasers in medical science · 2022Article
- Hair regrowth and maintenance in alopecia universalis patient treated with nonablative Er:YAG laser.Clinical case reports · 2021Article
- Characteristics of Non-Ablative Resurfacing of Soft Tissues by Repetitive Er:YAG Laser Pulse Irradiation.Lasers in surgery and medicine · 2021Article
- Nonablative transurethral Erbium:YAG laser treatment for chronic prostatitis/chronic pelvic pain syndrome: A prospective comparative study.Neurourology and urodynamics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
According to the standard Arrhenius relation, tissue damage is linearly dependent on the duration of exposure to elevated temperatures and exponentially dependent on the temperature itself. However, recently published measurements of damage threshold temperatures at extremely short exposure times (commonly present during laser treatments) exhibit a shift to temperatures that are higher than what would normally be expected from a single-process Arrhenius model. A novel variable heat shock (VHS) response model was developed that takes into account the observed deviation from the single-process Arrhenius relation, by assuming that the cell viability can be described as the combined effect of two biochemical processes that dominate cell survival characteristics at very short and very long exposure times. The potential implications of the VHS model are explored theoretically through an example of non-ablative laser resurfacing. The VHS model shows that under the appropriate conditions, very high temperature heat shocks can be generated within the superficial epithelium tissue layer without causing irreversible tissue damage. A mechanism of action for tissue regeneration by means of non-ablative resurfacing with the Er:YAG laser is proposed, which involves indirect triggering of tissue regeneration through intense heat shock to the epithelia, in addition to the tissue regeneration mechanism by means of direct thermal injury to deeper lying connective tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.