ArticleJournal of gastroenterology2019
Epidemiological analysis of achalasia in Japan using a large-scale claims database.
Article in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Global trends in incidence and prevalence of achalasia, 1925-2021: A systematic review and meta-analysis.United European gastroenterology journal · 2024Pooled it
- Modern treatment for achalasia: endoscopic and surgical therapies.The British journal of surgery · 2026Review
- Characteristics of the Esophageal Microbiota in Patients with Achalasia.Digestive diseases and sciences · 2026Article
- Idiopathic achalasia: unraveling the etiology and pathogenesis of an inflammatory disease.Gastroenterology report · 2026Review
- Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study.Journal of gastroenterology · 2025Observational
- Epidemiology and practice patterns of achalasia in Taiwan: A nationwide population-based cohort study.Journal of the Chinese Medical Association : JCMA · 2025Article
- Safety and efficacy of peroral endoscopic myotomy for treating achalasia in pediatric and geriatric patients: A meta-analysis.World journal of gastrointestinal endoscopy · 2024Article
- Two onset types of achalasia and the long-term course to diagnosis.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea.Gut and liver · 2023Article
- Assessment of the Physical Invasiveness of Peroral Endoscopic Myotomy during the Perioperative Period Based on Changes in Energy Metabolism.Metabolites · 2023Article
- Ethnic Differences in Clinical Presentations and Esophageal High-Resolution Manometry Findings in Patients with Achalasia.Dysphagia · 2023Article
- Per-oral endoscopic myotomy is safe and effective for pediatric patients with achalasia: A long-term follow-up study.World journal of gastroenterology · 2023Article
- Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan.Journal of neurogastroenterology and motility · 2022Article
- Achalasia.Nature reviews. Disease primers · 2022Review
- Impact of the COVID-19 pandemic on high-resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2022Article
- Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study.Journal of neurogastroenterology and motility · 2022Article
- Efficacy and safety of peroral endoscopic myotomy in 100 older patients.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Esophageal achalasia with severe malnutrition and liver enzyme elevation.Clinical journal of gastroenterology · 2022Article
- Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography-a large database analysis in Japan.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- The patient characteristics of esophageal carcinoma following laparoscopic myotomy for esophageal achalasia.Langenbeck's archives of surgery · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAchalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends.
methodsTo estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Patients with achalasia and coexistence of esophageal carcinoma were identified based on the diagnosis code registered. Interventional treatment was also evaluated.
resultsOf the total 5,493,650 populations, 385 were diagnosed with primary achalasia. The incidence was calculated as 0.81-1.37 per 100,000 person-years (male-to-female ratio was almost 1; mean age at diagnosis was 43.3 ± 14.4 years). The period prevalence was 7.0 per 100,000 persons. There were statistically significant trends of increase in the incidence and period prevalence over age groups (all p values < 0.0001). Four men with achalasia developed esophageal carcinoma, and the incidence of esophageal carcinoma with achalasia was estimated as 0.25 per 100 person-years. With regard to intervention, esophageal dilation was performed as a first treatment in 64.7% of patients, with repeat intervention required in 56.9% of these. The proportion of patients treated using peroral endoscopic myotomy (POEM) increased annually to 41.1% in 2017.
conclusionsIn Japan, the incidence and period prevalence of achalasia is comparable to that in other countries. The absolute risk of esophageal carcinoma is rather low. Esophageal dilation has been the mainstay of achalasia treatment, and the role of POEM has increased annually.
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