ArticleVirchows Archiv : an international journal of pathology2019
Histologic diagnosis and grading of esophageal acute graft-versus-host disease.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Intestinal involvement in graft versus host disease in children: An overview by the ESPGHAN Gastroenterology Committee.Journal of pediatric gastroenterology and nutrition · 2025Review
- A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD.Oxidative medicine and cellular longevity · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute intestinal graft-versus-host disease (GvHD) is a serious threat after allogeneic hematopoietic stem cell transplantation (alloHSCT). Although criteria for the histological diagnosis and grading of GvHD are well established for most parts of the gastrointestinal tract, evidence-based criteria have not yet been defined for the esophagus. Here, we evaluated esophageal biopsies obtained from 51 patients who underwent alloHSCT and compared the findings with those within the stomach and duodenum. In 32 of 51 biopsy samples of the esophagus, we identified a continuum of histological features of acute GvHD, ranging from vacuolar degeneration and single-cell apoptosis to the formation of clefts and mucosa denudation in advanced cases. These findings correlated with GvHD involving the stomach and duodenum and the clinical manifestations of GvHD in other organs. We therefore conclude that acute GvHD and esophageal GvHD can be diagnosed and graded histologically. Our findings may help to establish the histological diagnosis of acute GvHD using endoscopic biopsies from the esophagus and to explain the alterations observed in the esophageal mucosa in patients after alloHSCT.
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