Evidence map›Paper›PMID 30607535›Full record

ArticleJournal of neurology2019

Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease.

Claudio Liguori, Nicola Biagio Mercuri, Maria Albanese, Enrica Olivola, Alessandro Stefani, Mariangela Pierantozzi

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  10. Review
  11. Article
  12. Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  13. Review
  14. Article
  15. Excessive Daytime Sleepiness in Parkinson's Disease.Nature and science of sleep · 2022
    Review
  16. Article
  17. Review
  18. Review
  19. Sleep Issues in Parkinson's Disease and Their Management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Claudio LiguoriDepartment of Systems Medicine, Sleep Medicine Centre, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy. dott.claudioliguori@yahoo.it.ORCID http://orcid.org/0000-0003-2845-1332
Nicola Biagio MercuriNeurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Maria AlbaneseNeurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Enrica OlivolaParkinson and Movement Disorders Unit, Neurology Department, IRCCS Neuromed, Pozzilli, IS, Italy.
Alessandro StefaniUOSD Parkinson, University Hospital of Rome "Tor Vergata", Rome, Italy.
Mariangela PierantozziUOSD Parkinson, University Hospital of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITIstituto Neurologico Mediterraneo · IT

Funding

UCB Unrestricted grant
6 · The paper itself

Abstract

Excessive daytime sleepiness (EDS) may represent a disabling non-motor symptom in patients affected by Parkinson's disease (PD). This is a secondary analysis of a previous study documenting the improvement of nocturnal sleep in PD patients treated by rotigotine vs placebo. Here we tested the supposition that EDS may represent a distinct PD non-motor symptom occurring independently of other sleep-wake disorders; moreover, we verified whether EDS can be influenced by the improvement of nocturnal sleep in PD. In the present study, we evaluated the daytime sleepiness of PD patients treated with nocturnal administration of rotigotine (PD-Rot) vs placebo (PD-Pla), as measured by both subjective (Epworth Sleepiness Scale-ESS) and objective (Multiple Sleep Latency Test-MSLT) tools. We included 21 PD-Rot compared to 21 PD-Pla patients and documented no significant changes of both ESS and MSLT data between baseline and follow-up visits in both groups. Moreover, we found no correlations between nocturnal sleep improvement and diurnal sleepiness. Therefore, these data suggest that the improvement of nocturnal sleep in PD patients does not modify the daytime sleepiness, thus suggesting that diurnal sleepiness may occur independently of nocturnal sleep disturbances in PD patients.

Indexed as

AgedDisorders of Excessive SomnolenceDopamine AgonistsFemaleFollow-Up StudiesHumansMaleMiddle AgedParkinson DiseasePolysomnographySleep Wake DisordersTetrahydronaphthalenesThiophenesDopamine AgonistsrotigotineTetrahydronaphthalenesThiophenesESSExcessive daytime sleepinessMSLTParkinson’s diseaseRotigotineSleep-wake cycle

Identifiers

PMID30607535
OpenAlexW2907758749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.