ArticleChromosoma2019
Molecular structure of human synaptonemal complex protein SYCE1.
Article in Chromosoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The synaptonemal complex: structure, function, and clinical implications†.Biology of reproduction · 2026Article
- Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- A suppressor screenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Making a good egg: human oocyte health, aging, and in vitro development.Physiological reviews · 2023Review
- A Novel Frameshift Microdeletion of the TEX12 Gene Caused Infertility in Two Brothers with Nonobstructive Azoospermia.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- A suppressor screenbioRxiv : the preprint server for biology · 2023Article
- Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.Nature structural & molecular biology · 2023Article
- Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip.Communications biology · 2022Article
- TCFL5 deficiency impairs the pachytene to diplotene transition during spermatogenesis in the mouse.Scientific reports · 2022Article
- Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia.BMC medical genomics · 2022Article
- Novel exon mutation in SYCE1 gene is associated with non-obstructive azoospermia.Journal of cellular and molecular medicine · 2022Article
- Dissecting chicken germ cell dynamics by combining a germ cell tracing transgenic chicken model with single-cell RNA sequencing.Computational and structural biotechnology journal · 2022Article
- Alterations in synaptonemal complex coding genes and human infertility.International journal of biological sciences · 2022Review
- Targeted next-generation sequencing panel screening of 668 Chinese patients with non-obstructive azoospermia.Journal of assisted reproduction and genetics · 2021Article
- Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12.Nature structural & molecular biology · 2021Article
- Structural basis for the coiled-coil architecture of human CtIP.Open biology · 2021Article
- Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma.International journal of molecular sciences · 2021Article
- ZYP1 is required for obligate cross-over formation and cross-over interference inProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The reduction in chromosome number during meiosis is essential for the production of haploid germ cells and thereby fertility. To achieve this, homologous chromosomes are first synapsed together by a protein assembly, the synaptonemal complex (SC), which permits genetic exchange by crossing over and the subsequent accurate segregation of homologues. The mammalian SC is formed of a zipper-like array of SYCP1 molecules that bind together homologous chromosomes through self-assembly in the midline that is structurally supported by the central element. The SC central element contains five proteins-SYCE1, SYCE3, SIX6OS1, and SYCE2-TEX12-that permit SYCP1 assembly to extend along the chromosome length to achieve full synapsis. Here, we report the structure of human SYCE1 through solution biophysical methods including multi-angle light scattering and small-angle X-ray scattering. The structural core of SYCE1 is formed by amino acids 25-179, within the N-terminal half of the protein, which mediates SYCE1 dimerization. This α-helical core adopts a curved coiled-coil structure of 20-nm length in which the two chains are arranged in an anti-parallel configuration. This structure is retained within full-length SYCE1, in which long C-termini adopt extended conformations to achieve an elongated molecule of over 50 nm in length. The SYCE1 structure is compatible with it functioning as a physical strut that tethers other components to achieve structural stability of the SC central element.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.