ArticlePsychopharmacology2019
Pupillary reactivity to alcohol cues as a predictive biomarker of alcohol relapse following treatment in a pilot study.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Multimodal Psychophysiological Assessment of Craving in Patients With Alcohol Dependence During Virtual Reality Cue Exposure: Exploratory Single-Arm Clinical Study.JMIR serious games · 2026Article
- Attentional Bias, Pupillometry, and Spontaneous Blink Rate: Eye Characteristic Assessment Within a Translatable Nicotine Cue Virtual Reality Paradigm.JMIR serious games · 2024Article
- A Review of the Use of Gaze and Pupil Metrics to Assess Mental Workload in Gamified and Simulated Sensorimotor Tasks.Sensors (Basel, Switzerland) · 2024Review
- The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review.Journal of clinical medicine · 2024Review
- Exploring Attentional Bias toward Alcohol Content: Insights from Eye-Movement Activity.European addiction research · 2024Article
- An explorative single-arm clinical study to assess craving in patients with alcohol use disorder using Virtual Reality exposure (CRAVE)-study protocol.BMC psychiatry · 2023Observational
- Publication guidelines and recommendations for pupillary measurement in psychophysiological studies.Psychophysiology · 2022Article
- Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study.JMIR serious games · 2022Article
- The pupillary light reflex (PLR) as a marker for the ability to work or drive - a feasibility study.Journal of occupational medicine and toxicology (London, England) · 2021Article
- Validity and measurement invariance of the Addictions Neuroclinical Assessment incentive salience domain among treatment-seekers with alcohol use disorder.Journal of substance abuse treatment · 2021Article
- Pupillary Responses for Cognitive Load Measurement to Classify Difficulty Levels in an Educational Video Game: Empirical Study.JMIR serious games · 2021Article
- Pilot study: Improving attention bias modification of alcohol cues through concealed gaze-contingent feedback in alcohol dependence.Addictive behaviors reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleIdentifying the predictors of relapse in detoxified alcohol-dependent patients is crucial for effective surveillance procedures and the optimization of treatment. Physiological measures such as functional MRI activity and heart rate variability have been shown as potential markers of relapse prediction.
objectivesOur aim was to assess differential pupillary reactions to alcohol-related cues as an objective physiological candidate predictor of relapse.
methodsWe examined the relationship between cue-elicited pupillary reactions to alcohol stimuli and luminance-controlled neutral stimuli in 21 detoxified alcohol-dependent patients and subsequent relapse outcome at a 4-month follow-up.
resultsDifferential pupillary dilation to alcohol stimuli as compared to neutral stimuli at 150 to 250 ms after stimulus onset substantially improved the model prediction of relapse outcome (additional 27% of variance) beyond that achieved from five standardized questionnaires on alcohol craving, alcohol use, problematic use severity, depressive tendencies, and duration of abstinence (47% of variance). In contrast, alcohol craving did not improve relapse model prediction.
conclusionsThis pilot study shows that alcohol-dependent patients with greater pupillary dilation to alcohol stimuli are more vulnerable to relapse, and that pupillometry presents as an important tool for addiction science.
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