Evidence map›Paper›PMID 30607468›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole.

James Simpson, Adrienn Pálvölgyi, Ferenc A Antoni

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Cold spots are universal in protein-protein interactions.Protein science : a publication of the Protein Society · 2022
    Article
  4. Structure ofeLife · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

James SimpsonCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, Scotland, EH8 9XD, UK.
Adrienn PálvölgyiDivision of Preclinical Research, Egis Pharmaceuticals PLC, Budapest, Hungary.
Ferenc A AntoniCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, Scotland, EH8 9XD, UK. ferenc.antoni@ed.ac.uk.ORCID 0000-0002-9738-8173
Egis Pharmaceuticals (Hungary) · HUUniversity of Edinburgh · GB

Funding

Medical Research Council
6 · The paper itself

Abstract

In mammals, nine genes encode trans-membrane adenylyl cyclase (tmAC) isoforms that synthesize the intracellular messenger compound cAMP from ATP. As cAMP is produced in virtually all types of cell, isoform-selective modulators of tmAC would have major research and therapeutic potential. This study investigated the effects of fungicide imidazoles previously shown to suppress cAMP production in various tissues on the activities of tmAC isoforms AC1, 2, or 9 stably expressed in human embryonic kidney 293 cells. Intact cells, as well as crude membranes, were exposed to various imidazoles or known stimulators of tmAC and the ensuing changes in the production of cAMP analyzed. In crude membranes, the activity of AC9 in the presence of GDP-β-S was enhanced by miconazole with an EC

Indexed as

Adenylyl CyclasesCyclic AMPFungicides, IndustrialHEK293 CellsHumansImidazolesadenylate cyclase 9Adenylyl CyclasesCyclic AMPFungicides, IndustrialImidazolesAdenosine 3′5′monophosphateAdenylyl cyclaseCa2+/calcineurinTrans-membrane adenylyl cyclase

Identifiers

PMID30607468
OpenAlexW2907850136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.