ArticleThe ISME journal2019
An interspecies malate-pyruvate shuttle reconciles redox imbalance in an anaerobic microbial community.
Article in The ISME journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice.Nature communications · 2026Article
- Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome.Environmental microbiome · 2026Article
- Modeling reveals a metabolic basis of competition amongmSystems · 2025Article
- Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance.Cell metabolism · 2025Article
- Comparative proteogenomics reveals ecological and evolutionary insights into the organohalide-respiringApplied and environmental microbiology · 2025Article
- Ferroptosis: iron release mechanisms in the bioenergetic process.Cancer metastasis reviews · 2025Review
- A Study of the Community Relationships Between Methanotrophs and Their Satellites Using Constraint-Based Modeling Approach.International journal of molecular sciences · 2024Article
- FromApplied and environmental microbiology · 2024Article
- Exchange of Vitamin BJournal of bacteriology · 2022Article
- A gap-filling algorithm for prediction of metabolic interactions in microbial communities.PLoS computational biology · 2021Article
- Common principles and best practices for engineering microbiomes.Nature reviews. Microbiology · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbes in ecosystems often develop coordinated metabolic interactions. Therefore, understanding metabolic interdependencies between microbes is critical to deciphering ecosystem function. In this study, we sought to deconstruct metabolic interdependencies in organohalide-respiring consortium ACT-3 containing Dehalobacter restrictus using a combination of metabolic modeling and experimental validation. D. restrictus possesses a complete set of genes for amino acid biosynthesis yet when grown in isolation requires amino acid supplementation. We reconciled this discrepancy using flux balance analysis considering cofactor availability, enzyme promiscuity, and shared protein expression patterns for several D. restrictus strains. Experimentally,
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