Evidence map›Paper›PMID 30607017›Full record

ArticleCell research2019

STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice.

Xiaoling Liu, Haiping Wang, Yan Jiang, Qin Zheng, Matt Petrus, Mingmin Zhang, Sisi Zheng, Christian Schmedt, Xinzhong Dong, Bailong Xiao

Open access · bronzeAbstract read
In one paragraph

Article in Cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Orai1-mediated CaExperimental & molecular medicine · 2026
    Article
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  3. Heat-off responses of epidermal cells sensitizebioRxiv : the preprint server for biology · 2025
    Article
  4. eLife · 2025
    Article
  5. Article
  6. Review
  7. Thermosensing ability of TRPC5: current knowledge and unsettled questions.The journal of physiological sciences : JPS · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Xiaoling LiuState Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China.
Haiping WangState Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China.
Yan JiangState Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China.
Qin ZhengDepartments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, Howard Hughes Medical Institute, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Matt PetrusGenomics Institute of the Novartis Research Foundation, San Diego, CA, 92121, USA.
Mingmin ZhangState Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China.
Sisi ZhengBeijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, 100875, Beijing, China.
Christian SchmedtGenomics Institute of the Novartis Research Foundation, San Diego, CA, 92121, USA.
Xinzhong DongDepartments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, Howard Hughes Medical Institute, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Bailong XiaoState Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China. xbailong@mail.tsinghua.edu.cn.
Genomics Institute of the Novartis Research Foundation · USMcGovern Institute for Brain Research · USBeijing Normal University · CNCenter for Life Sciences · CNHoward Hughes Medical Institute · USJohns Hopkins University · USState Key Laboratory of Membrane BiologyTsinghua University · CN

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of ~33 °C, which ensures precise warm sensation. However, the underlying mechanisms remain unclear. Here we show that STIM1, an endoplasmic reticulum (ER) resident transmembrane protein that responds to both ER Ca

Indexed as

Hot TemperatureAnimalsAnimals, NewbornBehavior, AnimalCalciumCalcium ChannelsCalcium SignalingEndoplasmic ReticulumFemaleGanglia, SpinalGene Knockout TechniquesKeratinocytesMaleMiceMice, Inbred C57BLMice, KnockoutCalciumCalcium ChannelsORAI1 ProteinOrai1 protein, mouseOrai3 protein, mouseStim1 protein, mouseStromal Interaction Molecule 1

Identifiers

PMID30607017
PMCPMC6355819
OpenAlexW2907475519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.