ArticleEuropean journal of clinical nutrition2019
Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients.
Article in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Associations between Advanced Glycation End Products, Body Composition and Mediterranean Diet Adherence in Kidney Transplant Recipients.International journal of environmental research and public health · 2022Article
- The relationship between grip strength with health-related quality of life and mortality in hemodialysis patients.Nutrire : revista de Sociedade Brasileira de Alimentacao e Nutricao = journal of the Brazilian Society of Food and Nutrition · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced glycation end products (AGEs) are elevated in patients with renal failure and may potentially affect skeletal muscle. The aim of this study was to evaluate whether serum concentrations of AGEs are associated with muscle strength in hemodialysis (HD) patients, since this association is not clear in the literature.
methodsThis research has a cross-sectional design and included 96 patients on hemodialysis treatment (20-69 years). Serum AGEs (ELISA), three-day dietary records, anthropometric and bioimpedance variables and handgrip strength (HGS) were analysed. Serum AGEs were analyzed by ELISA test.
resultsMen's HGS were significantly higher than women's (p < 0.001). Serum AGEs of the individuals of the highest HGS quartile versus the lowest quartile were 11.27 ± 2.52 and 9.06 ± 2.14 (µg/mL), respectively (p = 0.02). After adjustment for potential confounders, the correlation between serum AGEs and HGS lost statistical significance. The main factors that were associated to muscle strength were aging, BMI, percentage of fat-free mass and serum albumin.
conclusionContrary to our hypothesis, serum AGEs were not associated with muscular strength in HD patients. These results suggest that serum AGE is not a good indicator of muscle strength in this population and others factors related to the disease may be more important and significant in reducing muscle strength than the serum concentrations of AGEs alone.
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