Evidence map›Paper›PMID 30606845›Full record

ArticleScience (New York, N.Y.)2019

DNA fragility in the parallel evolution of pelvic reduction in stickleback fish.

Kathleen T Xie, Guliang Wang, Abbey C Thompson, Julia I Wucherpfennig, Thomas E Reimchen, Andrew D C MacColl, Dolph Schluter, Michael A Bell, Karen M Vasquez, David M Kingsley

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 1 pooled it
27.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 1 synthesis or guideline pooled it, 226 citations in OpenAlex.

  1. Pooled it
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  10. Review
  11. Formation and biological implications of Z-DNA.Trends in genetics : TIG · 2026
    Review
  12. Characterization of Z-DNA dynamics across the tree of life.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Kathleen T XieDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3178-8959
Guliang WangDivision of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-6871-7540
Abbey C ThompsonDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6080-2038
Julia I WucherpfennigDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3471-6624
Thomas E ReimchenDepartment of Biology, University of Victoria, Victoria, BC, Canada.
Andrew D C MacCollSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0003-2102-6130
Dolph SchluterDepartment of Zoology, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-1683-7836
Michael A BellDepartment of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA. kingsley@stanford.edu.
Karen M VasquezDivision of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-6958-5073
David M KingsleyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA. kingsley@stanford.edu.ORCID 0000-0002-6401-6461
Howard Hughes Medical Institute · USStanford University · USThe University of Texas at Austin · USStony Brook University · USUniversity of British Columbia · CAUniversity of Nottingham · GBUniversity of Victoria · CA

Funding

Genomic Basis of Vertebrate DiversityP50HG002568 · NHGRI · STANFORD UNIVERSITY · PI KINGSLEY, DAVID M · 2002 to 2011
$29.2M
GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
REPAIR OF GENOME DESTABILIZING DNA STRUCTURESR01CA093729 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Karen M Vasquez · 2002 to 2026
$8.2M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA093729NHGRI NIH HHS P50 HG002568NIGMS NIH HHS T32 GM007790
6 · The paper itself

Abstract

Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (

Indexed as

Dinucleotide RepeatsDNA Breaks, Double-StrandedSequence DeletionAnimalsBiological EvolutionDNAEnhancer Elements, GeneticFish ProteinsNucleic Acid ConformationPelvisSmegmamorphaTranscription FactorsDNAFish ProteinsTranscription Factors

Identifiers

PMID30606845
PMCPMC6677656
OpenAlexW2907669909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.