Evidence map›Paper›PMID 30606815›Full record

ArticleClinical science (London, England : 1979)2019

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig.

John S Hammond, Fred Godtliebsen, Sonja Steigen, I Neil Guha, Judy Wyatt, Arthur Revhaug, Dileep N Lobo, Kim E Mortensen

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

John S HammondNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, U.K.
Fred GodtliebsenDepartment of Mathematics and Statistics, UiT - The Arctic University of Norway, Tromsø, Norway.
Sonja SteigenInstitute of Medical Biology, UiT - The Arctic University of Norway, Tromsø, Norway.
I Neil GuhaNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, U.K.
Judy WyattDepartment of Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, U.K.
Arthur RevhaugSurgical Research Laboratory, Institute of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Dileep N LoboNottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, U.K. Dileep.Lobo@nottingham.ac.uk.ORCID 0000-0003-1187-5796
Kim E MortensenSurgical Research Laboratory, Institute of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
University Hospital of North Norway · NOFreeman Hospital · GBLeeds Teaching Hospitals NHS Trust · GBNottingham Biomedical Research Centre · GBQueen's Medical Centre · GBUiT The Arctic University of Norway · NO

Funding

Arthritis Research UK 19891Department of HealthMedical Research Council MR/K00414X/1Medical Research Council MR/P021220/1
6 · The paper itself

Abstract

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine if terlipressin or direct portacaval shunting can modulate these effects. Pigs were randomized (

Indexed as

HepatectomyPortacaval Shunt, SurgicalAnimalsBlood Flow VelocityDisease Models, AnimalHepatic ArteryLiverLiver CirculationLiver FailureMalePortal PressurePortal VeinSus scrofaTerlipressinTerlipressinportacaval shuntpost-resection liver failureterlipressin

Identifiers

PMID30606815
PMCPMC6331658
OpenAlexW2907186851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.