Evidence map›Paper›PMID 30606754›Full record

ArticleG3 (Bethesda, Md.)2019

Activation of the Bile Acid Pathway and No Observed Antimicrobial Peptide Sequences in the Skin of a Poison Frog.

Megan L Civitello, Robert Denton, Michael A Zasloff, John H Malone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Megan L CivitelloInstitute of Systems Genomics, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269.
Robert DentonInstitute of Systems Genomics, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269.ORCID 0000-0002-8629-1376
Michael A ZasloffGeorgetown University School of Medicine, MedStar Georgetown Transplant Institute, Washington D.C. 20057.
John H MaloneInstitute of Systems Genomics, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269 john.malone@uconn.edu.ORCID 0000-0003-1369-3769
University of Connecticut · USGeorgetown University · USInstitute for Systems Biology · US

Funding

UPIT: Unleash the Potential of Intestinal TransplantationR01AI132389 · NIAID · GEORGETOWN UNIVERSITY · PI KROEMER, ALEXANDER HELMUT KURT · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI132389
6 · The paper itself

Abstract

The skin secretions of many frogs have genetically-encoded, endogenous antimicrobial peptides (AMPs). Other species, especially aposematic poison frogs, secrete exogenously derived alkaloids that serve as potent defense molecules. The origins of these defense systems are not clear, but a novel bile-acid derived metabolite, tauromantellic acid, was recently discovered and shown to be endogenous in poison frogs (

Indexed as

TranscriptomeAmphibian ProteinsAnimalsAntimicrobial Cationic PeptidesAnuraBile Acids and SaltsPhylogenySkinAmphibian ProteinsAntimicrobial Cationic PeptidesBile Acids and SaltsAnti-microbial peptidesbile acid pathwaydefensive secretionsphylogenetic history

Identifiers

PMID30606754
PMCPMC6385980
OpenAlexW2907447322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.