ArticleGenome research2019
An AR-ERG transcriptional signature defined by long-range chromatin interactomes in prostate cancer cells.
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Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Androgen receptor drives divergent chromatin accessibility programs in benign and malignant prostate epithelial cells.Nucleic acids research · 2026Article
- Review
- Molecular determinants of AR-enhancer interaction and cistrome reprogramming in prostate cancer progression.Endocrine-related cancer · 2026Review
- Circular RNA-based therapy targeting metabolic vulnerability of fatty acid synthesis overcomes castration-resistant prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer.Nature genetics · 2025Article
- Review
- Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.Nature genetics · 2024Article
- Loss of feedback regulation between FAM3B and androgen receptor driving prostate cancer progression.Journal of the National Cancer Institute · 2024Article
- ChIPr: accurate prediction of cohesin-mediated 3D genome organization from 2D chromatin features.Genome biology · 2024Article
- Long-range gene regulation in hormone-dependent cancer.Nature reviews. Cancer · 2023Review
- PET imaging of new target CDK19 in prostate cancer.European journal of nuclear medicine and molecular imaging · 2023Article
- MYC reshapes CTCF-mediated chromatin architecture in prostate cancer.Nature communications · 2023Article
- Phenotypic maps for precision medicine: a promising systems biology tool for assessing therapy response and resistance at a personalized level.Frontiers in network physiology · 2023Article
- Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture.Cancer discovery · 2022Article
- Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.Nature communications · 2022Article
- Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence.Cancer discovery · 2022Article
- Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.Nature genetics · 2022Article
- Review
- Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.Nature communications · 2021Article
- Genome-wide crosstalk between steroid receptors in breast and prostate cancers.Endocrine-related cancer · 2021Review
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 4 countries.
Zhizhuo Zhang *School of Computing, National University of Singapore, Singapore 117417.
Kern Rei Chng *Genome Institute of Singapore, Singapore 138672.
Shreyas Lingadahalli *Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China.ORCID 0000-0002-9609-6486
Zikai ChenGenome Institute of Singapore, Singapore 138672.
Mei Hui LiuGenome Institute of Singapore, Singapore 138672.
Huy Hoang DoGenome Institute of Singapore, Singapore 138672.
Shaojiang CaiGenome Institute of Singapore, Singapore 138672.
Nicola RinaldiComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Huay Mei PohGenome Institute of Singapore, Singapore 138672.
Guoliang LiGenome Institute of Singapore, Singapore 138672.
Ying Ying SungGenome Institute of Singapore, Singapore 138672.
Charlie L HengGenome Institute of Singapore, Singapore 138672.
Leighton J CoreDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
Si Kee TanGenome Institute of Singapore, Singapore 138672.
Xiaoan RuanGenome Institute of Singapore, Singapore 138672.
John T LisDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
Manolis KellisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Yijun RuanGenome Institute of Singapore, Singapore 138672.
Wing-Kin SungSchool of Computing, National University of Singapore, Singapore 117417.
Edwin CheungGenome Institute of Singapore, Singapore 138672.
Genome Institute of Singapore · SGUniversity of Macau · MOBroad Institute · USCornell University · USHuazhong Agricultural University · CNMassachusetts Institute of Technology · USNational University of Singapore · SG
Funding
COORDINATE GENE REGULATION IN ANIMAL CELLSR01GM025232 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIS, JOHN T · 1985 to 2020
$8.4MCell type specific epigenetic analysis to understand complex mechanisms underlying Alzheimer's disease phenotypesRF1AG054012 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2016 to 2016
$3.9MDistance-Hi-C: Creating Photo Activated X-linkers To Define Nuclear ArchitectureU01HL129958 · NHLBI · CORNELL UNIVERSITY · PI LIN, HENING, LIS, JOHN T · 2015 to 2019
$3.6MEpigenomic variation atlas across human tissues and individuals in GTExU01HG007610 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS · 2014 to 2016
$3.0MCOORDINATE GENE REGULATION IN ANIMAL CELLSR37GM025232 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIS, JOHN THOMAS · 1995 to 2004
$2.5MNHGRI NIH HHS U01 HG007610NHLBI NIH HHS U01 HL129958NIA NIH HHS RF1 AG054012NIGMS NIH HHS R01 GM025232NIGMS NIH HHS R37 GM025232
Abstract
The aberrant activities of transcription factors such as the androgen receptor (AR) underpin prostate cancer development. While the AR
Indexed as
Gene Expression Regulation, NeoplasticTranscription, GeneticCell Line, TumorChromatinGene Regulatory NetworksGenome, HumanHumansMaleOncogene Proteins, FusionPolymorphism, Single NucleotideProstatic NeoplasmsReceptors, AndrogenRNA, Long NoncodingTranscriptional Regulator ERGChromatinERG protein, humanOncogene Proteins, FusionReceptors, AndrogenRNA, Long NoncodingTranscriptional Regulator ERG
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.