ArticleAJNR. American journal of neuroradiology2019
"Ears of the Lynx" MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 80 citations in OpenAlex.
- "Ears of the lynx" sign on MRI: A radiologic clue to hereditary spastic paraplegia.Radiology case reports · 2026Article
- Genotypic and Phenotypic Profile of Hereditary Spastic Paraplegia in Children: A Single-Centre Study from Northern India.Indian pediatrics · 2026Article
- Decoding early gait disturbance using the 'ear of the lynx' imaging sign in hereditary spastic paraplegia.Internal medicine journal · 2026Article
- Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology.Journal of neuroinflammation · 2026Article
- Expanding the genetic and clinical landscapes of hereditary spastic paraplegia (HSP): a cohort study of 103 families.Orphanet journal of rare diseases · 2026Article
- Article
- Bridging the anatomical gap: evolutionary conservation of genetic mechanisms in corpus callosum disorders across human, mouse, and zebrafish.Frontiers in molecular neuroscience · 2026Review
- 소아 신경영상에서 보이는 비선천성 원인의 영상 소견: 임상 화보.Journal of the Korean Society of Radiology · 2026Review
- Imaging patterns of paediatric CNS mitochondrial disorders.Neuroradiology · 2026Review
- Clinical characteristics and gene mutation analysis of a family with hereditary spastic paraplegia type 11: a case report.Journal of medical case reports · 2025Article
- Children with Genetically Confirmed Hereditary Spastic Paraplegia: A Single-Center Experience.Children (Basel, Switzerland) · 2025Article
- Expanding the Phenotypic Spectrum of SPG7 Rare Damaging Variants: Insights From a Hungarian Cohort.Clinical genetics · 2025Article
- "Ears of the Lynx" Sign on Brain MRI in Siblings With Spastic Paraplegia: A Case Report.Annals of the Child Neurology Society · 2025Article
- Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.Brain : a journal of neurology · 2025Article
- Spinal cord cross sign: a potential marker for hereditary spastic paraplegia type 5.Neuroradiology · 2025Observational
- Ears of the Lynx on Neuroimaging in a Patient with COQ4-Associated Hereditary Spastic Paraplegia.Movement disorders clinical practice · 2025Article
- Altered tubulin detyrosination due to SVBP malfunction induces cytokinesis failure and senescence, underlying a complex hereditary spastic paraplegia.Aging cell · 2025Article
- "Ear of the Lynx" Sign in Hereditary Spastic Paraplegia 76.Journal of clinical neurology (Seoul, Korea) · 2025Article
- A rare case of hereditary spastic paraplegia: Case report.Radiology case reports · 2025Article
- Article
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Authors and funding
19 authors at 15 institutions in 6 countries.
Funding
Abstract
background and purposeThe "ears of the lynx" MR imaging sign has been described in case reports of hereditary spastic paraplegia with a thin corpus callosum, mostly associated with mutations in the MATERIALS AND
methodsFour independent raters, blinded to the diagnosis, determined whether the ears of the lynx sign was present in each of a set of 204 single anonymized FLAIR and T1-weighted MR images from 34 patients with causal mutations associated with SPG11 or Spastic Paraplegia type 15 (SPG15). 34 healthy controls, and 34 patients with multiple sclerosis.
resultsThe interrater reliability for FLAIR images was substantial (Cohen κ, 0.66-0.77). For these images, the sensitivity of the ears of the lynx sign across raters ranged from 78.8 to 97.0 and the specificity ranged from 90.9 to 100. The accuracy of the sign, measured by area under the receiver operating characteristic curve, ranged from very good (87.1) to excellent (93.9).
conclusionsThe ears of the lynx sign on FLAIR MR imaging is highly specific for the most common genetic subtypes of hereditary spastic paraplegia with a thin corpus callosum. When this sign is present, there is a high likelihood of a genetic mutation, particularly associated with SPG11 or SPG15, even in the absence of a family history.
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