Evidence map›Paper›PMID 30606614›Full record

ArticleNeuron2019

Mechanisms of Spatiotemporal Selectivity in Cortical Area MT.

Ambarish S Pawar, Sergei Gepshtein, Sergey Savel'ev, Thomas D Albright

Abstract read
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Characterizing Spatiotemporal Population Receptive Fields in Human Visual Cortex with fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ambarish S PawarSystems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: ambarish@salk.edu.
Sergei GepshteinSystems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Center for Spatial Perception and Concrete Experience, School of Cinematic Arts, University of Southern California, Los Angeles, CA 90089, USA.
Sergey Savel'evDepartment of Physics, Loughborough University, Loughborough LE11 3TU, UK.
Thomas D AlbrightSystems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Funding

Core Grant for Vision ResearchP30EY019005 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALBRIGHT, THOMAS D · 2009 to 2018
$7.7M
Neural mechanisms of visual sensitivityR01EY029117 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALBRIGHT, THOMAS D, GEPSHTEIN, SERGEI · 2019 to 2023
$2.4M
Neural mechanisms underlying adaptive optimization of visual sensitivityR01EY018613 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALBRIGHT, THOMAS D, GEPSHTEIN, SERGEI · 2011 to 2013
$1.5M
NEI NIH HHS P30 EY019005NEI NIH HHS R01 EY018613NEI NIH HHS R01 EY029117
6 · The paper itself

Abstract

Cortical sensory neurons are characterized by selectivity to stimulation. This selectivity was originally viewed as a part of the fundamental "receptive field" characteristic of neurons. This view was later challenged by evidence that receptive fields are modulated by stimuli outside of the classical receptive field. Here, we show that even this modified view of selectivity needs revision. We measured spatial frequency selectivity of neurons in cortical area MT of alert monkeys and found that their selectivity strongly depends on luminance contrast, shifting to higher spatial frequencies as contrast increases. The changes of preferred spatial frequency are large at low temporal frequency, and they decrease monotonically as temporal frequency increases. That is, even interactions among basic stimulus dimensions of luminance contrast, spatial frequency, and temporal frequency strongly influence neuronal selectivity. This dynamic nature of neuronal selectivity is inconsistent with the notion of stimulus preference as a stable characteristic of cortical neurons.

Indexed as

AnimalsCortical ExcitabilityMacaca mulattaMaleSensory Receptor CellsVisual Cortexarea MTcontrastexcitationinhibitioninhibition-stabilized networkprimatereceptive fieldspatial frequencytemporal frequencyvisual cortex

Identifiers

PMID30606614
PMCPMC6398985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.