Evidence map›Paper›PMID 30606240›Full record

ArticleTrials2019

Effect and feasibility of non-linear periodized resistance training in people with COPD: study protocol for a randomized controlled trial.

Erik Frykholm, Peter Klijn, Didier Saey, Hieronymus W H van Hees, Per Stål, Thomas Sandström, Ann Sörlin, François Maltais, André Nyberg

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03518723 (Effect and Feasibility of Non-linear Periodized Resistance Training in People With Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03518723 nacompletednot on this map

Effect and Feasibility of Non-linear Periodized Resistance Training in People With Chronic Obstructive Pulmonary Disease: a Randomized Controlled Multicenter Trial

TypeinterventionalSponsorUmeå UniversityRan2018 to 2023Enrolled57ConditionsPulmonary Disease, Chronic ObstructiveArmsNon-linear Periodized Resistance Training, Resistance training
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Measuring and monitoring skeletal muscle function in COPD: current perspectives.International journal of chronic obstructive pulmonary disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Erik FrykholmDepartment of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden. erik.frykholm@umu.se.ORCID http://orcid.org/0000-0002-3212-4708
Peter KlijnDepartment of Pulmonology, Pulmonary Rehabilitation Centre Merem, Hilversum, The Netherlands.
Didier SaeyCentre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de médecine, Université Laval, Québec, QC, Canada.
Hieronymus W H van HeesDepartment of Pulmonary Diseases, Radboud UMC, Nijmegen, The Netherlands.
Per StålDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Thomas SandströmDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Ann SörlinDepartment of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden.
François MaltaisCentre de recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculté de médecine, Université Laval, Québec, QC, Canada.
André NybergDepartment of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden.
Umeå University · SEInstitut universitaire de cardiologie et de pneumologie de Québec · CAAmsterdam UMC Location University of Amsterdam · NLRadboud University Nijmegen · NL

Funding

The Swedish heart and lung association E 127/16Vetenskapsrådet 2016-01802
6 · The paper itself

Abstract

backgroundIn people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic goal of COPD management, for which resistance training is recommended. However, current guidelines for resistance training in COPD mainly focus on improving muscle strength which only reflects one aspect of limb-muscle function and does not address the issue of reduced muscle endurance. The latter is of importance considering that the reduction in limb-muscle endurance often is greater than that of muscle weakness, and also, limb-muscle endurance seems to be closer related to walking capacity as well as arm function than to limb-muscle strength within this group of people. Thus, strategies targeting multiple aspects of the decreased muscle function are warranted to increase the possibility for an optimal effect for the individual patient. Periodized resistance training, which represents a planned variation of resistance training variables (i.e., volume, intensity, frequency, etc.), is one strategy that could be used to target limb-muscle strength as well as limb-muscle endurance within the same exercise regimen.

methodsThis is an international, multicenter, randomized controlled trial comparing the effect and feasibility of non-linear periodized resistance training to traditional non-periodized resistance training in people with COPD. Primary outcomes are dynamic limb-muscle strength and endurance. Secondary outcomes include static limb-muscle strength and endurance, functional performance, quality of life, dyspnea, intramuscular adaptations as well as the proportion of responders. Feasibility of the training programs will be assessed and compared on attendance rate, duration, satisfaction, drop-outs as well as occurrence and severity of any adverse events. DISCUSSION: The proposed trial will provide new knowledge to this research area by investigating and comparing the feasibility and effects of non-linear periodized resistance training compared to traditional non-periodized resistance training. If the former strategy produces larger physiological adaptations than non-periodized resistance training, this project may influence the prescription of resistance training in people with COPD.

trial registrationClinicalTrials.gov, ID: NCT03518723 . Registered on 13 April 2018.

Indexed as

Resistance TrainingAdultAgedAged, 80 and overFeasibility StudiesHumansMiddle AgedMulticenter Studies as TopicMuscle StrengthPatient ComplianceProspective StudiesPulmonary Disease, Chronic ObstructiveQuality of LifeRandomized Controlled Trials as TopicSample SizeFunctional performanceLimb-muscle enduranceLimb-muscle strengthPulmonary disease, chronic obstructive

Identifiers

PMID30606240
PMCPMC6318913
OpenAlexW2921402175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.