Evidence map›Paper›PMID 30606230›Full record

ArticleGenome biology2019

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens.

Dimitra Repana, Joel Nulsen, Lisa Dressler, Michele Bortolomeazzi, Santhilata Kuppili Venkata, Aikaterini Tourna, Anna Yakovleva, Tommaso Palmieri, Francesca D Ciccarelli

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed
31.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 706 citations in OpenAlex.

  1. Trial
  2. Article
  3. Disentangling Heterogeneous Molecular Networks for Multi-Omics-Driven Cancer Driver Discovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  18. MAVISp: A modular structure-based framework for protein variant effects.Protein science : a publication of the Protein Society · 2026
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dimitra RepanaCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Joel NulsenCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Lisa DresslerCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Michele BortolomeazziCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Santhilata Kuppili VenkataCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Aikaterini TournaCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Anna YakovlevaCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Tommaso PalmieriCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Francesca D CiccarelliCancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK. francesca.ciccarelli@crick.ac.uk.ORCID 0000-0002-9325-0900
King's College London · GB

Funding

Cancer Research UK 25487Cancer Research UK C43634/A25487
6 · The paper itself

Abstract

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .

Indexed as

Databases, GeneticGenes, NeoplasmGenetic HeterogeneityHumansCancer genesCancer genomics screensCancer heterogeneitySystems-level properties

Identifiers

PMID30606230
PMCPMC6317252
OpenAlexW2949066452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.