Evidence map›Paper›PMID 30606204›Full record

Trial reportReproductive biology and endocrinology : RB&E2019

Letrozole-associated controlled ovarian hyperstimulation in breast cancer patients versus conventional controlled ovarian hyperstimulation in infertile patients: assessment of oocyte quality related biomarkers.

Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer, Isabelle Demeestere

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Reproductive biology and endocrinology : RB&E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02661932 (Efficiency and Safety Study of Ovarian Stimulation With Letrozole for Fertility Preservation in Breast Cancer Patients), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02661932 phase4completednot on this map

Efficiency and Safety Study of Ovarian Stimulation With Letrozole for Fertility Preservation in Breast Cancer Patients

TypeinterventionalSponsorErasme University HospitalRan2012 to 2024Enrolled65ConditionsBreast Neoplasms, FertilityArmsLetrozole
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Oranite GoldratFertility Clinic, Department of Obstetrics and Gynecology, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium. oranite.goldrat@erasme.ulb.ac.be.ORCID http://orcid.org/0000-0002-7794-3133
Geraldine Van Den SteenResearch Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Eric Gonzalez-MerinoFertility Clinic, Department of Obstetrics and Gynecology, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Julie DechèneResearch Laboratory on Human Reproduction, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Christine GervyLaboratory of Chemistry, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Anne DelbaereFertility Clinic, Department of Obstetrics and Gynecology, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Fabienne DevrekerFertility Clinic, Department of Obstetrics and Gynecology, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Viviane De MaertelaerIRIBHM and SBIM, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Isabelle DemeestereFertility Clinic, Department of Obstetrics and Gynecology, CUB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium.
Université Libre de Bruxelles · BE

Funding

Fonds De La Recherche Scientifique - FNRS 7.4612.13Fonds De La Recherche Scientifique - FNRS (BE) 7.4528.15
6 · The paper itself

Abstract

backgroundFertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of Let-COH on the follicular microenvironment has been poorly investigated, although a high androgen/estrogen ratio was previously associated with low oocyte quality.

methodsIn this prospective study, follicular fluid (FF) steroid levels (estradiol, testosterone, progesterone) and cumulus cell (CC) gene expression related to oocyte quality (HAS2, PTGS2, GREM1) were compared between 23 BC patients undergoing Let-COH for FP and 24 infertile patients undergoing conventional COH without letrozole. All patients underwent an antagonist COH cycle, and ovulation was triggered with hCG or GnRHa in both groups.

resultsFF estradiol levels were significantly lower while testosterone levels were significantly higher in the study group compared to controls irrespective of the trigger method. However, estradiol levels increased significantly with GnRHa triggering compared to hCG in the study group (median = 194.5 (95.4-438) vs 64.4 (43.8-152.4) ng/ml, respectively, p < 0.001), but not in the control group (median = 335.5 (177.5-466.7) vs 354 (179-511) ng/ml, respectively). After hCG trigger, Cumulus cell (CC) gene expression was lower in the study group compared to the control group, and difference was significant for PTGS2. Conversely, CC gene expression of PTGS2 and GREM1 was significantly higher in the study group compared to controls when ovulation was triggered with GnRHa.

conclusionsLet-COH triggered with hCG may negatively impact oocyte quality. However, ovulation triggering with GnRHa may improve the oocyte microenvironment and cumulus cell genes expression in Let-COH, suggesting a positive impact on oocyte quality in breast cancer patients.

trial registrationClinicaltrials.gov - NCT02661932 , registered 25 January 2016, retrospectively registered.

Indexed as

Breast NeoplasmsAdolescentAdultCellular MicroenvironmentEstradiolFemaleFertility PreservationFollicular FluidGenetic MarkersHumansInfertility, FemaleLetrozoleOocytesOvulation InductionProgesteroneTestosteroneEstradiolGenetic MarkersLetrozoleProgesteroneTestosteroneBreast cancerControlled ovarian hyperstimulationCumulus cellsFollicular fluidGene expressionLetrozoleOocyte quality

Identifiers

PMID30606204
PMCPMC6318989
OpenAlexW2913598492

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.