ArticleWorld journal of surgical oncology2019
Specific risk factors contributing to early and late recurrences of intrahepatic cholangiocarcinoma after curative resection.
Article in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Artificial intelligence in predicting recurrence after first-line treatment of liver cancer: a systematic review and meta-analysis.BMC medical imaging · 2024Pooled it
- Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: a systematic review and meta-analysis.BMC cancer · 2024Pooled it
- Recombinant human adenovirus p53 combined with transcatheter arterial chemoembolization for liver cancer: A meta-analysis.PloS one · 2023Pooled it
- Predictive factors of microvascular invasion in patients with intrahepatic mass-forming cholangiocarcinoma based on magnetic resonance images.Abdominal radiology (New York) · 2023Trial
- The Effect of Neoadjuvant Therapy on Post-Recurrence Overall Survival After Curative Resection for Intrahepatic Cholangiocarcinoma.Annals of surgical oncology · 2026Article
- The prognostic value analysis of PIV, PLR, LMR, NPR, and NLR in hilar cholangiocarcinoma.BMC cancer · 2026Article
- Body composition radiomics combined with machine learning for early recurrence prediction in intrahepatic cholangiocarcinoma following curative surgery: A Multi-Center study.European journal of nuclear medicine and molecular imaging · 2026Article
- Preoperative Prognostic Score for Patients with Intrahepatic Cholangiocarcinoma Undergoing Curative-Intent Resection.Medical sciences (Basel, Switzerland) · 2026Article
- Machine Learning-Based Model to Predict Survival in Resectable Intrahepatic Cholangiocarcinoma.Cancer management and research · 2026Article
- Very Early Recurrence Following Liver Resection for Intrahepatic Cholangiocarcinoma: Is It Predictable by Clinical Preoperative Factors?ANZ journal of surgery · 2025Article
- Establishment and characterization of three gemcitabine-resistant human intrahepatic cholangiocarcinoma cell lines.Scientific reports · 2025Article
- Who benefits from adjuvant chemotherapy? Identification of early recurrence in intrahepatic cholangiocarcinoma patients after curative-intent resection using machine learning algorithms.Frontiers in oncology · 2025Article
- Epidemiology of biliary tract cancer in China: A narrative review.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
- Cox model risk score to predict survival of intrahepatic cholangiocarcinoma after ultrasound-guided ablation.Abdominal radiology (New York) · 2024Article
- Call to Improve the Quality of Prediction Tools for Intrahepatic Cholangiocarcinoma Resection: A Critical Appraisal, Systematic Review, and External Validation Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
- Machine learning radiomics to predict the early recurrence of intrahepatic cholangiocarcinoma after curative resection: A multicentre cohort study.European journal of nuclear medicine and molecular imaging · 2023Article
- Preoperative neutrophil-to-lymphocyte ratio is prognostic for early recurrence after curative intrahepatic cholangiocarcinoma resection.Annals of hepato-biliary-pancreatic surgery · 2023Article
- ASO Author Reflections: Searching for Prognostic Factors of Early Recurrence in Intrahepatic Cholangiocarcinoma.Annals of surgical oncology · 2022Article
- Systematic Review and Meta-Analysis of Prognostic Factors for Early Recurrence in Intrahepatic Cholangiocarcinoma After Curative-Intent Resection.Annals of surgical oncology · 2022Review
- Role of eIF3C Overexpression in Predicting Prognosis of Intrahepatic Cholangiocarcinoma.Digestive diseases and sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMost intrahepatic cholangiocarcinoma (ICC) patients experienced tumor recurrences even after curative resection, but the optimal cut-off time point and the specific risk factors for early and late recurrences of ICC have not been clearly defined. The objective of the current study was to define specific risk factors for early and late recurrences of ICC after radical hepatectomy.
methodsIncluded in this study were 259 ICC patients who underwent curative surgery at our hospital between January 2005 and December 2009. Recurrences in these patients were followed-up prospectively. Piecewise regression model and the minimum P value approach were used to estimate the optimal cut-off time point for early and late recurrences. Then, Cox's proportional hazards regression model was used to identify specific independent risk factors for early and late recurrences.
resultsEarly and late recurrences occurred in 130 and 74 patients, respectively, and the 12th month was confirmed as the optimal cut-off time point for early and late recurrences. Cox's proportional hazards regression model showed that microvascular invasion (HR = 2.084, 95% CI 1.115-3.897, P = 0.021), multiple tumors (HR = 2.071, 95% CI 1.185-3.616, P = 0.010), abnormal elevation of serum CA19-9 (HR = 1.619, 95% CI 1.076-2.437, P = 0.021), and the negative hepatitis B status (HR = 1.650, 95% CI 1.123-2.427, P = 0.011) were independent risk factors for early recurrence, and HBV-DNA level > 10
conclusionSpecific risk factors and mechanisms may relate to early and late recurrences of ICC after curative resection.
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