ArticleBMC pregnancy and childbirth2019
Adverse maternal and neonatal outcomes among singleton pregnancies in women of very advanced maternal age: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2019Pooled it
- Advanced maternal age increases the risk of adverse neonatal outcomes: a comparative study in Ethiopia.BMC pregnancy and childbirth · 2025Article
- Unraveling the complexity of selected adverse neonatal outcomes in India: a multilevel analysis using data from a nationally representative sample survey.BMC pregnancy and childbirth · 2025Article
- Article
- Association between parity and adverse maternal and neonatal outcomes: a population-based cross-sectional study.Frontiers in medicine · 2025Article
- Pregnancy Outcomes Following Assisted Reproductive Technology in Advanced Maternal Age Primiparous Women: A Retrospective Cohort Study.International journal of women's health · 2025Article
- Predictors of perinatal mortality in emerging regions of Ethiopia: Evidence from EDHS 2016.PloS one · 2025Article
- Birth outcomes of advanced maternal age pregnancies.Central European journal of public health · 2024Article
- Article
- Comparison of the perinatal outcomes of expected high ovarian response patients and normal ovarian response patients undergoing frozen-thawed embryo transfer in natural/small amount of HMG induced ovulation cycles.BMC public health · 2024Article
- Maternal and Neonatal Perinatal Outcomes of Singleton Pregnancies in Advanced-Age Women Undergoing IVF/ICSI-ET Compared with Spontaneous Conception: A Retrospective Propensity Score Matched Cohort Study.International journal of general medicine · 2024Article
- The Prediction of IVF Outcomes with Autologous Oocytes and the Optimal MII Oocyte/Embryo Number for Live Birth at Advanced Maternal Age.Medicina (Kaunas, Lithuania) · 2023Article
- [Maternal and perinatal morbidities associated to advanced age in pregnant women].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Trends, influencing factors and prediction analysis of under-five and maternal mortality rates in China from 1991 to 2020.Frontiers in public health · 2023Article
- The effects of advanced maternal age on perinatal mortality in Ethiopia: A systematic review and meta-analysis.SAGE open medicine · 2023Review
- The effect of maternal age and duration of labor on perinatal and neonatal outcomes: a retrospective cohort study.Annals of translational medicine · 2022Article
- Neonatal Mortality Rate and Its Determinants: A Community-Based Panel Study in Ethiopia.Frontiers in pediatrics · 2022Article
- Advanced Maternal Age Impairs Myelination in Offspring Rats.Frontiers in pediatrics · 2022Article
- Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles.Frontiers in endocrinology · 2022Article
- Adverse Neonatal Outcomes and Associated Risk Factors: A Case-Control Study.Global pediatric health · 2022Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an increasing prevalence of women who tend to delay childbirth until a very advanced age. However, there is sparse data regarding very advanced maternal age (vAMA) and the interplay between vAMA and assisted reproductive technology (ART) on adverse perinatal outcomes. The study aimed to assess the risk of adverse maternal and neonatal outcomes of vAMA women (≥43 years), and to investigate the effect of maternal age on adverse maternal and neonatal outcomes in ART pregnancies.
methodsData was obtained from a population-based retrospective cohort of women who delivered in Ontario, Canada, between April 1st, 2012 and March 31st, 2015. The adjusted relative risks (ARR) and 95% confidence intervals (CI) for adverse maternal and neonatal outcomes were estimated by using multivariate log-binomial regression models among age groups. All models were stratified by the utilization of ART (ART and spontaneous conceptions).
resultsWomen at vAMA had a higher risk of composite outcome comprised of preeclampsia, intrauterine growth retardation, stillbirth, and placental abruption than the younger counterparts (ARR = 1.38, 95% CI: 1.23-1.55 compared to mothers aged 20-34; ARR = 1.26, 95% CI: 1.12-1.42 compared to mothers aged 35-42). Increased risk of the primary outcome in ART compared to spontaneous conception was only observed in women aged 20-34 years (ARR = 1.24, 95% CI: 1.14-1.35). For women conceived with ART, the risk for the primary outcome significantly increased in women at vAMA (ARR = 1.29, 95% CI: 1.01-1.65 compared to mothers aged 20-34; ARR = 1.36, 95% CI: 1.06-1.74 compared to mothers aged 35-42).
conclusionWomen at vAMA have higher risks of adverse maternal and neonatal outcomes. Although the utilization of ART may carry an independent role for adverse perinatal outcomes, it does not further enhance the adverse effect of vAMA.
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