ArticleBMC infectious diseases2019
Laboratory evaluation of four HIV/syphilis rapid diagnostic tests.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Independent clinic-based evaluation of dual POCTs for screening for HIV and syphilis in men who have sex with men in Italy, Malta, Peru, and the United Kingdom.BMC infectious diseases · 2024Pooled it
- Updates on epidemiology and diagnostic tests of syphilis in South Korea.The Korean journal of internal medicine · 2026Review
- Integration of HIV, Hepatitis B, and C, and sexually transmitted infections services: A scoping review of the benefits and challenges.PloS one · 2026Article
- Community-Based Rapid Testing for HIV in Europe and Central Asia: A Narrative Review of Models, Effectiveness, and Implementation Challenges.Infection and drug resistance · 2026Review
- Partitioning and probe-based quantitative PCR assays for the wastewater monitoring ofJournal of water and health · 2025Article
- Diagnostic performance of the Hightop Rapid Diagnostic Test for the detection of antiBMJ open · 2025Article
- A comprehensive One Health investigation of erythromycin and quinupristin/dalfopristin resistantJournal of water and health · 2025Article
- Update on syphilis diagnostics.Current opinion in infectious diseases · 2025Review
- Spatiotemporal assessment of pathogenicJournal of water and health · 2024Article
- External quality assessment to support the WHO ProSPeRo study for the evaluation of two dual HIV/syphilis point-of-care tests in seven countries.BMC infectious diseases · 2024Article
- Factors influencing the positivity of diagnostic tests for congenital syphilis.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Editorial: STI awareness day: diagnosis and control of STIs in LMICs.Frontiers in reproductive health · 2024Article
- Assessment of the Accuracy, Usability and Acceptability of a Rapid Test for the Simultaneous Diagnosis of Syphilis and HIV Infection in a Real-Life Scenario in the Amazon Region, Brazil.Diagnostics (Basel, Switzerland) · 2023Article
- Canadian Public Health Laboratory Network guidelines for the use of point-of-care tests forJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- The Laboratory Diagnosis of Syphilis.Journal of clinical microbiology · 2021Review
- Clinical presentation of congenital syphilis in a rotavirus vaccine cohort study in Lusaka: a case series.Journal of medical case reports · 2021Article
- Double-Antigen Lateral Flow Immunoassay for the Detection of Anti-HIV-1 and -2 Antibodies Using Upconverting Nanoparticle Reporters.Sensors (Basel, Switzerland) · 2021Article
- A Landscape Analysis of Offering HIV Testing Services Within Family Planning Service Delivery.Frontiers in reproductive health · 2021Article
- Article
- Estimating syphilis seroprevalence among patients in a sexually transmitted infections clinic in Lilongwe, Malawi.International journal of STD & AIDS · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundSexually transmitted infections, such as HIV and syphilis, are one of the major health care problems worldwide, especially in low- and middle income countries. HIV screening programmes have been widely used for many years. The introduction of rapid point-of-care tests (RDTs) that can detect both HIV and syphilis, using one single blood specimen, would be a promising tool to integrate the detection of syphilis into HIV programmes and so improve the accessibility of syphilis testing and treatment.
methodsAs part of the World Health Organization pre-qualification of in vitro diagnostics assessment, the laboratory performance of four dual HIV-Syphilis rapid diagnostic tests (SD Bioline HIV/Syphilis Duo, DPP HIV-Syphilis Assay, Multiplo Rapid TP/HIV Antibody Test and Insti Multiplex HIV-1/HIV-2/Syphilis Antibody Test) was assessed using a well characterized multiregional panel of stored sera specimens.
resultsIn total 400 specimens were tested with each assay, resulting in excellent sensitivities and specificities for HIV, ranging from 99.5 to 100% and from 93.5 to 99.5%, respectively. Results obtained for the Treponema pallidum antibodies were lower, with the lowest sensitivity of 73.5% for Multiplo and the highest of 87% for SD Bioline. Specificities ranged from 99.0 to 100%.
conclusionAlthough these results suggest that the tests could further improve in accuracy in detection of treponemal antibodies, their introduction into screening programmes to increase the accessibility of HIV/Syphilis diagnosis and treatment for difficult to reach populations in the world is promising.
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