Evidence map›Paper›PMID 30606080›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2019

Regulation of CX3CL1 Expression in Human First-Trimester Decidual Cells: Implications for Preeclampsia.

S Joseph Huang, Chie-Pein Chen, Lynn Buchwalder, Ya-Chun Yu, Longzhu Piao, Chun-Yen Huang, Frederick Schatz, Charles J Lockwood

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

S Joseph Huang1 Department of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chie-Pein Chen3 Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Lynn Buchwalder4 Clinical Research Support Lab, Yale Cancer Center, New Haven, CT, USA.
Ya-Chun Yu1 Department of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Longzhu Piao5 Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Chun-Yen Huang1 Department of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Frederick Schatz2 Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.
Charles J Lockwood2 Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.
E-Da Hospital · TWUniversity of South Florida · USI-Shou University · TWMackay Memorial Hospital · TWThe Ohio State University · USYale Cancer Center · US

Funding

The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaR01HD056123 · NICHD · YALE UNIVERSITY · PI HUANG, SE-TE JOSEPH · 2008 to 2012
$1.8M
NICHD NIH HHS R01 HD056123
6 · The paper itself

Abstract

C-X3-C motif ligand 1 (CX3CL1) mediates migration, survival, and adhesion of natural killer (NK) cells, monocytes, and T-cells to endothelial/epithelial cells. Aberrant numbers and/or activation of these decidual immune cells elicit preeclampsia development. Decidual macrophages and NK cells are critical for implantation, while macrophage-derived tumor necrosis factor-α (TNF-α), interleukin-1 β (IL-1β), and NK cell-derived interferon-γ (IFN-γ) are associated with preeclampsia development. Thus, serum and decidual levels of CX3CL1 from first-trimester pregnancy and preeclampsia-complicated term pregnancy were examined by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. The effects of incubating primary human first-trimester decidual cells (FTDCs) with estradiol + medroxyprogesterone acetate + either IL-1β or TNF-α and/or IFN-γ on CX3CL1 expression were also assessed by quantitative reverse transcription-polymerase chain reaction and ELISA. The inhibition of each signaling pathway with each kinase and nuclear factor κB (NFκB) inhibitors was evaluated by ELISA. Chemotaxis of CD56

Indexed as

Cell MovementCells, CulturedChemokine CX3CL1DeciduaEstradiolFemaleGene Expression RegulationHumansInterferon-gammaInterleukin-1betaKiller Cells, NaturalMedroxyprogesterone AcetatePre-EclampsiaPregnancyPregnancy Trimester, FirstTumor Necrosis Factor-alphaChemokine CX3CL1EstradiolInterferon-gammaInterleukin-1betaMedroxyprogesterone AcetateTumor Necrosis Factor-alphaCX3CL1decidual celldNK cellpreeclampsia

Identifiers

PMID30606080
PMCPMC6949968
OpenAlexW2908246390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.