ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Interictal spike connectivity in human epileptic neocortex.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- EEG CONNECT: A proposed reporting checklist for EEG-based connectivity studies in clinical epilepsy research.Epilepsia open · 2026Review
- Neurosurgery Network Pattern Analysis with 2nd Generation Ensembles.Computer graphics forum : journal of the European Association for Computer Graphics · 2026Article
- Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state.Brain communications · 2025Article
- Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.Annals of clinical and translational neurology · 2024Article
- Modeling the Interictal Epileptic State for Therapeutic Development with Tetanus Toxin.Brain sciences · 2024Review
- A biophysically constrained brain connectivity model based on stimulation-evoked potentials.Journal of neuroscience methods · 2024Article
- Spike-induced cytoarchitectonic changes in epileptic human cortex are reduced via MAP2K inhibition.Brain communications · 2024Article
- Identifying sources of human interictal discharges with travelling wave and white matter propagation.Brain : a journal of neurology · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- A biophysically constrained brain connectivity model based on stimulation-evoked potentials.bioRxiv : the preprint server for biology · 2023Article
- Self-limited childhood epilepsies are disorders of the perisylvian communication system, carrying the risk of progress to epileptic encephalopathies-Critical review.Frontiers in neurology · 2023Review
- INTUITION: a data platform to integrate human epilepsy clinical care and support for discovery.Frontiers in digital health · 2023Article
- Epileptic seizures and link to memory processes.AIMS neuroscience · 2022Article
- Highly consistent temporal lobe interictal spike networks revealed from foramen ovale electrodes.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone.Frontiers in neurology · 2021Article
- Modulation of locomotor behaviors by location-specific epileptic spiking and seizures.Epilepsy & behavior : E&B · 2021Article
- DUSP4 appears to be a highly localized endogenous inhibitor of epileptic signaling in human neocortex.Neurobiology of disease · 2020Article
- Identifying targets for preventing epilepsy using systems biology of the human brain.Neuropharmacology · 2020Review
- Sleep and Epilepsy Link by Plasticity.Frontiers in neurology · 2020Article
- Reproducibility of interictal spike propagation in children with refractory epilepsy.Epilepsia · 2019Article
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Authors and funding
7 authors.
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Abstract
objectiveInterictal spikes are a biomarker of epilepsy, yet their precise roles are poorly understood. Using long-term neocortical recordings from epileptic patients, we investigated the spatial-temporal propagation patterns of interictal spiking.
methodsInterictal spikes were detected in 10 epileptic patients. Short time direct directed transfer function was used to map the spatial-temporal patterns of interictal spike onset and propagation across different cortical topographies.
resultsEach patient had unique interictal spike propagation pattern that was highly consistent across times, regardless of the frequency band. High spiking brain regions were often not spike onset regions. We observed frequent spike propagations to shorter distances and that the central sulcus forms a strong barrier to spike propagation. Spike onset and seizure onset seemed to be distinct networks in most cases.
conclusionsPatients in epilepsy have distinct and unique network of causal propagation pattern which are very consistent revealing the underlying epileptic network. Although spike are epileptic biomarkers, spike origin and seizure onset seems to be distinct in most cases. SIGNIFICANCE: Understanding patterns of interictal spike propagation could lead to the identification patient-specific epileptic networks amenable to surgical or other treatments.
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