Evidence map›Paper›PMID 30605491›Full record

ArticlePLoS medicine2019

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Mattias Johansson, Robert Carreras-Torres, Ghislaine Scelo, Mark P Purdue, Daniela Mariosa, David C Muller, Nicolas J Timpson, Philip C Haycock, Kevin M Brown, Zhaoming Wang and 103 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 6 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Pooled it
  5. Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
  6. Pooled it
  7. Review
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  18. Lipid metabolism reprogramming in renal cell carcinomas.Medical oncology (Northwood, London, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

113 authors at 20 institutions in 18 countries.

Mattias JohanssonInternational Agency for Research on Cancer (IARC), Lyon, France.
Robert Carreras-TorresInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0002-2925-734X
Ghislaine SceloInternational Agency for Research on Cancer (IARC), Lyon, France.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Daniela MariosaInternational Agency for Research on Cancer (IARC), Lyon, France.
David C MullerImperial College, London, United Kingdom.
Nicolas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-7141-9189
Philip C HaycockMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-5001-3350
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0002-8558-6711
Zhaoming WangSt. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Yuanqing YeDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Matthieu FollInternational Agency for Research on Cancer (IARC), Lyon, France.
Valerie GaborieauInternational Agency for Research on Cancer (IARC), Lyon, France.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0001-6538-9705
Leandro M ColliDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Peng LiInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0002-0682-9819
Jean-Guillaume GarnierCentre National de Genotypage, Institut de Genomique, Centre de l'Energie Atomique et aux Energies Alternatives, Evry, France.
Helene BlancheFondation Jean Dausset - Centre d'Etude du Polymorphisme Humain, Paris, France.
Anne BolandCentre National de Genotypage, Institut de Genomique, Centre de l'Energie Atomique et aux Energies Alternatives, Evry, France.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Egor ProkhortchoukFederal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Moscow, Russian Federation.
Konstantin G SkryabinFederal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Moscow, Russian Federation.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Sanja Radojevic-SkodricInstitute of Pathology, Medical School of Belgrade, Belgrade, Serbia.ORCID 0000-0002-5395-8285
Simona OgnjanovicMayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, United States of America.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ivana HolcatovaInstitute of Public Health and Preventive Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID 0000-0002-1366-0337
Vladimir JanoutDepartment of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic.
Dana MatesNational Institute of Public Health, Bucharest, Romania.ORCID 0000-0002-6219-9807
Anush MukeriyaRussian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.ORCID 0000-0002-6847-9295
Stefan RascuCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.
David ZaridzeRussian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.
Vladimir BenckoInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Eleonora FabianovaRegional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.ORCID 0000-0002-5519-8427
Viorel JingaCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.ORCID 0000-0001-7632-5328
Jolanta LissowskaThe M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Marie NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Peter RudnaiNational Public Health Center, National Directorate of Environmental Health, Budapest, Hungary.
Simone BenhamouINSERM U946, Paris, France.
Geraldine Cancel-TassinCeRePP, Paris, France.ORCID 0000-0002-9583-6382
Olivier CussenotCeRePP, Paris, France.ORCID 0000-0002-9912-0533
Elisabete WeiderpassDepartment of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.ORCID 0000-0003-2237-0128
Börje LjungbergDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Raviprakash Tumkur SitaramDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Christel HäggströmDepartment of Biobank Research, Umeå University, Umeå, Sweden.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0002-9356-2015
Susan J JordanQIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0002-4566-1414
Gianluca Severi"Health across generations" team, CESP Inserm, Facultés de Médicine Université Paris-Sud, UVSQ, Université Paris-Saclay, Gustave Roussy, Villejuif, France.ORCID 0000-0001-7157-419X
Ingrid WinshipDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.ORCID 0000-0001-8535-6003
Kristian HveemK. G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Lars J VattenDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Tony FletcherLondon School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.ORCID 0000-0003-3385-200X
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0118-0341
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Rosamonde E BanksLeeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, United Kingdom.ORCID 0000-0002-0042-8715
Peter J SelbyNational Institute for Health Research Diagnostic Evidence Cooperative, Division of Surgery, Imperial College London, St Mary's Hospital, London, United Kingdom.
Douglas F EastonDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0003-1294-4124
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Satu MännistöNational Institute for Health and Welfare, Helsinki, Finland.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0002-3834-1535
Peter E ClarkVanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America.
Todd L EdwardsDepartment of Medicine, Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt Genetics Institute, Nashville, Tennessee, United States of America.ORCID 0000-0003-4318-6119
Loren LipworthVanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America.
Susan M GapsturAmerican Cancer Society, Atlanta, Georgia, United States of America.ORCID 0000-0002-1934-2110
Victoria L StevensAmerican Cancer Society, Atlanta, Georgia, United States of America.ORCID 0000-0003-0259-4407
Hallie CarolDana-Farber Cancer Institute, Boston, Massachusetts, United States of America.ORCID 0000-0001-8890-9785
Matthew L FreedmanDana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Mark M PomerantzDana-Farber Cancer Institute, Boston, Massachusetts, United States of America.ORCID 0000-0003-4914-1157
Eunyoung ChoBrown University, Providence, Rhode Island, United States of America.
Kathryn M WilsonHarvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
J Michael GazianoBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Howard D SessoHarvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0003-0074-1098
Alexander S ParkerDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, Florida, United States of America.
Jeanette E Eckel-PassowDepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0002-4440-3368
Richard J KahnoskiDivision of Urology, Spectrum Health, Grand Rapids, Michigan, United States of America.
Brian R LaneDivision of Urology, Spectrum Health, Grand Rapids, Michigan, United States of America.
Sabrina L NoyesVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan, United States of America.
David PetilloVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan, United States of America.ORCID 0000-0001-7234-4644
Bin Tean TehVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan, United States of America.
Ulrike PetersCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Garnet L AndersonWHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0001-5087-7837
Lisa JohnsonFred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, Indiana, United States of America.
Julie BuringBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
I-Min LeeBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Wong-Ho ChowDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Lee E MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.ORCID 0000-0002-5957-8283
Timothy EisenUniversity of Cambridge, Cambridge, United Kingdom.
Marc HenrionThe Institute of Cancer Research, London, United Kingdom.ORCID 0000-0003-1242-839X
James LarkinRoyal Marsden NHS Foundation Trust, London, United Kingdom.
Poulami BarmanDepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.ORCID 0000-0002-4604-9868
Bradley C LeibovichDepartment of Urology, Mayo Clinic, Rochester, Minnesota, United States of America.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, Massachusetts, United States of America.ORCID 0000-0002-9201-3217
G Mark LathropMcGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.
Jean-Francois DeleuzeCentre National de Genotypage, Institut de Genomique, Centre de l'Energie Atomique et aux Energies Alternatives, Evry, France.
Marc GunterInternational Agency for Research on Cancer (IARC), Lyon, France.
James D McKayInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0002-1787-3874
Xifeng WuDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Richard S HoulstonThe Institute of Cancer Research, London, United Kingdom.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America.
Caroline ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
J Brent RichardsDepartments of Medicine, Human Genetics, Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-3746-9086
Richard M MartinMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-7992-7719
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-1407-8314
Paul BrennanInternational Agency for Research on Cancer (IARC), Lyon, France.ORCID 0000-0002-0518-8714
National Institutes of Health · USCentre international de recherche sur le cancer · FRBrigham and Women's Hospital · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USUniversity of Bristol · GBFondation Jean Dausset-CEPH · FRKarolinska Institutet · SEMayo Clinic in Florida · USThe University of Texas MD Anderson Cancer Center · USVanderbilt University · USAmerican Cancer Society · USCarol Davila University of Medicine and Pharmacy · ROCharles University · CZInstitute of Cancer Research · GBInstitut Universitaire de France · FRInternational Hereditary Cancer Center · PLMasaryk Memorial Cancer Institute · CZMayo Clinic · USNorwegian University of Science and Technology · NO

Funding

Pooled genome-wide analysis of kidney cancer riskU01CA155309 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCELO, GHISLAINE · 2011 to 2014
$3.7M
Molecular pathways linking obesity and RCC tumorigenesis (PQ1)R01CA170298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GU, JIAN · 2012 to 2015
$2.1M
Cancer Research UK 19169Cancer Research UK 24390Cancer Research UK 6858Cancer Research UK C18281/A19169CIHRDepartment of Health RP-PG-0707-10101Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/3NCI NIH HHS R01 CA170298NCI NIH HHS U01 CA155309Wellcome Trust 202802/Z/16/ZWorld Health Organization 001
6 · The paper itself

Abstract

backgroundSeveral obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation. METHODS AND

findingsGenetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sample MR framework. The effect on RCC risk was estimated by calculating odds ratios (ORSD) for a standard deviation (SD) increment in each risk factor. The MR analysis indicated that higher body mass index increases the risk of RCC (ORSD: 1.56, 95% confidence interval [CI] 1.44-1.70), with comparable results for waist-to-hip ratio (ORSD: 1.63, 95% CI 1.40-1.90) and body fat percentage (ORSD: 1.66, 95% CI 1.44-1.90). This analysis further indicated that higher fasting insulin (ORSD: 1.82, 95% CI 1.30-2.55) and diastolic blood pressure (DBP; ORSD: 1.28, 95% CI 1.11-1.47), but not systolic blood pressure (ORSD: 0.98, 95% CI 0.84-1.14), increase the risk for RCC. No association with RCC risk was seen for lipids, overall type 2 diabetes, or fasting glucose.

conclusionsThis study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk.

Indexed as

Blood GlucoseBlood PressureBody Mass IndexCarcinoma, Renal CellDiabetes Mellitus, Type 2FemaleGenetic MarkersGenome-Wide Association StudyHumansInsulinKidney NeoplasmsLipidsMaleMendelian Randomization AnalysisObesityRisk FactorsBlood GlucoseGenetic MarkersInsulinLipids

Identifiers

PMID30605491
PMCPMC6317776
OpenAlexW2907490175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.