ArticlePloS one2019
Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Insights Into Stroke Risk and Prediction for Underweight Individuals.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- Correlation of risk factors for ischemic stroke with uric acid/creatinine ratio and cerebral vascular hemodynamic index (CVHI) in physical examination population.Pakistan journal of medical sciences · 2025Article
- Association Between Body Mass Index and Functional Outcomes in Patients With Intracerebral Hemorrhage.Neurology · 2024Article
- Do Weight Changes Affect the Association between Smoking Cessation and the Risk of Stroke Subtypes in Korean Males?International journal of environmental research and public health · 2023Article
- Body Mass Index Measured Repeatedly over 42 Years as a Risk Factor for Ischemic Stroke: The HUNT Study.Nutrients · 2023Article
- Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Association between long-term weight-change trajectory and cardiovascular disease risk by physical activity level.Scientific reports · 2022Article
- Clinical epigenetics and restoring of metabolic health in severely obese patients undergoing batriatric and metabolic surgery.Updates in surgery · 2022Review
- Article
- The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system.Preventive medicine reports · 2021Article
- Knowledge, Prevention Practice and Associated Factors of Stroke Among Hypertensive and Diabetic Patients - A Systematic Review.Risk management and healthcare policy · 2021Review
- Enriching the Study Population for Ischemic Stroke Therapeutic Trials Using a Machine Learning Algorithm.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverweight is known as a risk factor for ischemic stroke. However, the effect of weight change on the development of ischemic stroke remains controversial. We investigated the relationship between weight change and the risk of ischemic stroke using a nationwide population-based cohort.
methodsOur study enrolled 11,084,683 participants (Mean age 49.7±13.5 years, range 20-114 years) in the Korean National Health Screening Program from 2009 to 2012. Weight change was calculated using the difference between the baseline weight and the weight at health screening four years prior to the baseline. The occurrence of newly-diagnosed ischemic stroke was observed until the end of 2015. We categorized the study population according to weight change and performed multivariable analysis to compare the risk.
resultsIschemic stroke was newly diagnosed in 113,591 subjects. The crude incidence rates of ischemic stroke per 1000 person-years according to the change in body weight were 3.059, 1.906, and 1.491 in the <-5%, ±5%, and ≥+5% groups, respectively. After adjusting all variables, the hazard ratio (HR) of ischemic stroke was higher in subjects who underwent weight loss (HR 1.152) or weight gain (HR 1.087) than in those who maintained their weight. When analyzed by eight groups of 5% intervals, the risk showed a U-shaped curve with those who maintained their weight showing the lowest risk.
conclusionsThe risk of ischemic stroke was gradually increased in those who lost or gained more than 5% of their weight over four years, after adjusting for confounders. We should be aware of the increased risk of ischemic stroke in people who undergo weight change and should identify and manage the cause of weight change.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.