Evidence map›Paper›PMID 30605412›Full record

ArticleCirculation research2019

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

Joel L Berry, Wuqiang Zhu, Yao Liang Tang, Prasanna Krishnamurthy, Ying Ge, John P Cooke, Yabing Chen, Daniel J Garry, Huang-Tian Yang, Namakkal Soorapan Rajasekaran and 23 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Progress in Bioengineering Strategies for Heart Regenerative Medicine.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Cardiac Tissue Engineering for the Treatment of Myocardial Infarction.Journal of cardiovascular development and disease · 2021
    Review
  7. Mass Customized Outlook for Regenerative Heart Failure Care.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Joel L BerryFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
Wuqiang ZhuFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
Yao Liang TangVascular Biology Center, Medical College of Georgia, Augusta University (Y.T.).
Prasanna KrishnamurthyFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
Ying GeDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.).
John P CookeDepartment of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.).
Yabing ChenDepartment of Pathology (Y.C., N.S.R.), University of Alabama at Birmingham.
Daniel J GarryLillehei Heart Institute, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis (D.J.G.).
Huang-Tian YangShanghai Institutes for Biological Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), China (H.-T.Y.).
Namakkal Soorapan RajasekaranDepartment of Pathology (Y.C., N.S.R.), University of Alabama at Birmingham.
Walter J KochDepartment of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (W.J.K.).
Song LiDepartment of Bioengineering, University of California at Los Angeles (S.L.).
Keitaro DomaeDepartment of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Japan (K.D.).
Gangjian QinFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
Ke ChengDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh (K.C.).
Timothy J KampDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, (Y.G., T.J.K.).
Lei YeNational Heart Research Institute Singapore, National Heart Centre Singapore (L.Y.).
Shijun HuInstitute for Cardiovascular Science, Medical College of Soochow University, Suzhou, China (S.H.).
Brenda M OgleDepartment of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN (B.M.O.).
Jack M RogersFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.
E Dale AbelDivision of Endocrinology and Metabolism, Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine (E.D.A.).
Michael E DavisWallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory University School of Medicine, Atlanta (M.E.D.).
Sumanth D PrabhuDivision of Cardiovascular Disease and Comprehensive Cardiovascular Center, Department of Medicine (S.D.P.), University of Alabama at Birmingham.
Ronglih LiaoStanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.).
William T PuDepartment of Cardiology, Boston Children's Hospital, MA (W.T.P.).
Yibin WangDepartment of Anesthesiology and Medicine (Y.W.), David Geffen School of Medicine, University of California, Los Angeles.
Peipei PingDepartment of Physiology (P.P.), David Geffen School of Medicine, University of California, Los Angeles.
Nenad BursacDepartment of Biomedical Engineering, Duke University, Durham, NC (N.B.).
Gordana Vunjak-NovakovicDepartment of Biomedical Engineering and Department of Medicine, Columbia University, New York City, NY (G.V.-N.).
Joseph C WuStanford Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, CA (R.L., J.C.W.).
Roberto BolliInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY (R.B.).
Philippe MenaschéDepartment of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Paris, France (P.M.).
Jianyi ZhangFrom the Department of Biomedical Engineering (J.L.B., W.Z., P.K., G.Q., J.M.R., J.Z.), University of Alabama at Birmingham.

Funding

Progenitor Cell Biology Consortium Administrative Coordinating CenterU01HL099997 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2009 to 2015
$29.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
PCTC Administrative Coordinating CenterU24HL134763 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, JENNIFER S., TERRIN, MICHAEL L · 2016 to 2022
$7.9M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Targeted Nanoparticles for Stem Cell Redirecting and Regenerative MedicineR01HL123920 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2015 to 2023
$4.8M
Reductive Stress Induces Proteotoxic Cardiac DiseaseR01HL118067 · NHLBI · UNIVERSITY OF UTAH · PI NAMAKKAL SOORAPPAN, RAJASEKARAN · 2013 to 2021
$4.5M
Hypoxia and cardiac stem cell homingR01HL086555 · NHLBI · UNIVERSITY OF CINCINNATI · PI TANG, YAO LIANG · 2008 to 2019
$3.5M
Mechanisms that Govern and Promote Cardiovascular RegenerationR01HL148599 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J., GARRY, MARY G · 2019 to 2022
$3.0M
Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
BLRD VA I01 BX004426BLRD VA IK6 BX003617NHLBI NIH HHS R01 HL076485NHLBI NIH HHS R01 HL086555NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL118067NHLBI NIH HHS R01 HL123920NHLBI NIH HHS R01 HL128563NHLBI NIH HHS R01 HL128694NHLBI NIH HHS R01 HL129798NHLBI NIH HHS R01 HL131017NHLBI NIH HHS R01 HL136165NHLBI NIH HHS R01 HL137093NHLBI NIH HHS R01 HL137204NHLBI NIH HHS R01 HL148599NHLBI NIH HHS R13 HL147533NHLBI NIH HHS R56 HL142627NHLBI NIH HHS U01 HL099997NHLBI NIH HHS U01 HL134764NHLBI NIH HHS U24 HL134763NIAMS NIH HHS R01 AR070029NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present, and >40 scientists presented their latest work on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers, and physicians in the field of cardiovascular sciences met and discussed the most recent advances in their work and proposed future strategies for overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical, and mechanical cues to cells to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here, we present some important perspectives that emerged from this meeting.

Indexed as

Biological Science DisciplinesBiomedical EngineeringBiomedical ResearchHeart FailureInterdisciplinary CommunicationAnimalsCooperative BehaviorDiffusion of InnovationHeartHumansMyocardiumRecovery of FunctionRegenerationbioengineeringheart failuremyocardiumstem cellstissue engineering

Identifiers

PMID30605412
PMCPMC6350935

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.