Evidence map›Paper›PMID 30605394›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis.

Madeleine M Puissant, Clarissa Muere, Vladislav Levchenko, Anna D Manis, Paul Martino, Hubert V Forster, Oleg Palygin, Alexander Staruschenko, Matthew R Hodges

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of KThe American journal of pathology · 2025
    Article
  4. Deletion ofiScience · 2024
    Article
  5. Repeated seizures lead to progressive ventilatory dysfunction in SSJournal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  10. Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. KGlia · 2021
    Article
  15. Article
  16. Review
  17. Review
  18. Expression, localization, and functional properties of inwardly rectifying KAmerican journal of physiology. Renal physiology · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Madeleine M PuissantDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Clarissa MuereDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Vladislav LevchenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Anna D ManisDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Paul MartinoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Medical College of Wisconsin · USCarthage College · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
NHLBI NIH HHS R01 HL122358NHLBI NIH HHS R35 HL135749NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

Acute and chronic homeostatic pH regulation is critical for the maintenance of optimal cellular function. Renal mechanisms dominate global pH regulation over longer time frames, and rapid adjustments in ventilation compensate for acute pH and CO

Indexed as

AnimalsBlood Gas AnalysisHydrogen-Ion ConcentrationHypokalemiaKir5.1 ChannelMaleMutationPotassium Channels, Inwardly RectifyingPotassium, DietaryRatsRats, Inbred DahlKir5.1 ChannelPotassium Channels, Inwardly RectifyingPotassium, Dietarycontrol of breathingion channelspH regulation

Identifiers

PMID30605394
PMCPMC6436665
OpenAlexW2906998650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.