Evidence map›Paper›PMID 30605331›Full record

ArticleJournal of medicinal chemistry2019

Design and in Vivo Characterization of A

Dilip K Tosh, Harsha Rao, Amelia Bitant, Veronica Salmaso, Philip Mannes, David I Lieberman, Kelli L Vaughan, Julie A Mattison, Amy C Rothwell, John A Auchampach and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. An updated review of enantioselective syntheses and biological actions of carbanucleosides.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. P2YACS pharmacology & translational science · 2025
    Article
  3. Article
  4. Review
  5. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  6. Selective modulation of epileptic tissue by an adenosine ABritish journal of pharmacology · 2024
    Article
  7. Article
  8. Structure activity relationships of 5-HTEuropean journal of medicinal chemistry · 2023
    Article
  9. Article
  10. Article
  11. Development of Bicyclo[3.1.0]hexane-Based AMolecules (Basel, Switzerland) · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Dilip K Tosh
Harsha Rao
Amelia BitantDepartment of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
Veronica Salmaso
Philip Mannes
David I Lieberman
Kelli L VaughanSoBran BioSciences , SoBran, Inc. , 4000 Blackburn Lane , Burtonsville , Maryland 20866 , United States.
Julie A MattisonTranslational Gerontology Branch , National Institute on Aging Intramural Research Program , 16701 Elmer School Road, Building 103 , Dickerson , Maryland 20842 , United States.
Amy C RothwellDepartment of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
John A AuchampachDepartment of Pharmacology , Medical College of Wisconsin , 8701 Watertown Plank Road , Milwaukee , Wisconsin 53226 , United States.
Antonella CiancettaSchool of Pharmacy , Queen's University Belfast , 96 Lisburn Road , Belfast BT9 7BL , U.K.
Naili Liu
Zhenzhong Cui
Zhan-Guo Gao
Marc L Reitman
Oksana Gavrilova
Kenneth A JacobsonORCID 0000-0001-8104-1493
National Institutes of Health · USMedical College of Wisconsin · USInstitute on Aging · USQueen's University Belfast · GB

Funding

Aging Intervention StudiesZIAAG000356 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTISON, JULIE · 2013 to 2025
$21.7M
Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Computer Modeling of G Protein-Coupled ReceptorsZIADK031126 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$6.6M
Role of brown adipose tissue (BAT) in energy balanceZIADK075064 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.6M
What can body temperature tell us about energy homeostasis?ZIADK075063 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.6M
Pharmacologic approaches to the treatment of obesityZIADK075062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.5M
Adenosine Signaling During Post-Infarction Remodeling and Heart FailureR01HL133589 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2017 to 2020
$1.7M
Intramural NIH HHS ZIA AG000356Intramural NIH HHS ZIA DK031117Intramural NIH HHS ZIA DK075063NHLBI NIH HHS R01 HL133589
6 · The paper itself

Abstract

(N)-Methanocarba ([3.1.0]bicyclohexyl) adenosines and corresponding ribosides were synthesized to identify novel A

Indexed as

AdenosineAdenosine A1 Receptor AgonistsAnimalsBridged Bicyclo CompoundsCHO CellsCricetulusDrug DesignHEK293 CellsHumansMacaca fascicularisMaleMice, Inbred C57BLMolecular Docking SimulationMolecular StructureReceptor, Adenosine A1Structure-Activity RelationshipAdenosineAdenosine A1 Receptor AgonistsBridged Bicyclo CompoundsReceptor, Adenosine A1

Identifiers

PMID30605331
PMCPMC6467784
OpenAlexW2908228106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.