ArticleJournal of the American Chemical Society2019
Direct Carbon Isotope Exchange through Decarboxylative Carboxylation.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification.Angewandte Chemie (International ed. in English) · 2026Article
- Shape-Conserving Atom Replacements.Chemical reviews · 2026Review
- Article
- Photolysis of COJournal of the American Chemical Society · 2026Article
- An IntegratedACS catalysis · 2026Article
- Vanadium-Mediated Carbon Isotope Exchange of Terminal Alkenes.Journal of the American Chemical Society · 2025Article
- Carbon isotopic labelling of carboxylic acids enabled by organic photoredox-catalysed cyanation.Nature synthesis · 2025Article
- Effect of 6,6'-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling.ACS catalysis · 2024Article
- A metal-catalysed functional group metathesis approach to the carbon isotope labelling of carboxylic acids.Nature chemistry · 2024Article
- Carbon isotope exchange for pharmaceutical radiolabelling through metal-catalysed functional group metathesis.Nature chemistry · 2024Article
- Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling.Nature communications · 2024Article
- Core-Labeling (Radio) Synthesis of Phenols.Organic letters · 2023Article
- Molecular Editing of Pyrroles via a Skeletal Recasting Strategy.ACS central science · 2023Article
- Robust and General Late-Stage Methylation of Aryl Chlorides: Application to Isotopic Labeling of Drug-like Scaffolds.ACS catalysis · 2023Article
- Unlocking full and fast conversion in photocatalytic carbon dioxide reduction for applications in radio-carbonylation.Nature communications · 2023Article
- Rapid Access to Carbon-Isotope-Labeled Alkyl and Aryl Carboxylates Applying Palladacarboxylates.JACS Au · 2023Article
- Aldehyde-catalysed carboxylate exchange in α-amino acids with isotopically labelled CONature chemistry · 2022Article
- Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges.JACS Au · 2022Review
- Convergent Synthesis of (Tetrahedron letters · 2021Article
- 1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long-sought-after mimetics forProceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A two-step degradation-reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented. Simple activation via redox-active ester formation was followed by nickel-mediated decarboxylative carboxylation to afford a range of complex compounds with ample isotopic incorporations for drug metabolism and pharmacokinetic studies. The practicality and operational simplicity of the protocol were demonstrated by its use in an industrial carbon-14 radiolabeling setting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.