ArticleAnalytical chemistry2019
Multicolor Discrete Frequency Infrared Spectroscopic Imaging.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Computational Mass Spectrometry Imaging in the Era of AI.Chemical reviews · 2026Review
- Multispectral Infrared Colony Phenotyping for High-Throughput Microbiological Control of Waters.Journal of biophotonics · 2026Article
- Enabling Chemical Holography: A Comprehensive Framework and Implementation.IEEE photonics journal · 2025Article
- Exploring Feature Selection with Deep Learning for Kidney Tissue Microarray Classification Using Infrared Spectral Imaging.Bioengineering (Basel, Switzerland) · 2025Article
- Microbial Identification Through Multispectral Infrared Imaging of Colonies: A New Type of Morpho-Spectral Fingerprinting.Microbial biotechnology · 2025Article
- Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging from Sparse Data for Gynecologic Cancer Tissue Subtyping.Analytical chemistry · 2024Article
- Cervical Cancer Tissue Analysis Using Photothermal Midinfrared Spectroscopic Imaging.Chemical & biomedical imaging · 2024Article
- Rapid and Label-Free Histopathology of Oral Lesions Using Deep Learning Applied to Optical and Infrared Spectroscopic Imaging Data.Journal of personalized medicine · 2024Article
- Article
- Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging.Nature communications · 2023Article
- High-speed scanless entire bandwidth mid-infrared chemical imaging.Nature communications · 2023Article
- Article
- On the Limit of Detection in Infrared Spectroscopic Imaging.Applied spectroscopy · 2022Article
- Label-Free Infrared Spectroscopic Imaging Reveals Heterogeneity of β-Sheet Aggregates in Alzheimer's Disease.The journal of physical chemistry letters · 2021Article
- Design Considerations for Discrete Frequency Infrared Microscopy Systems.Applied spectroscopy · 2021Article
- Rapid brain structure and tumour margin detection on whole frozen tissue sections by fast multiphotometric mid-infrared scanning.Scientific reports · 2021Article
- Concurrent Vibrational Circular Dichroism Measurements with Infrared Spectroscopic Imaging.Analytical chemistry · 2021Article
- Mid-infrared metabolic imaging with vibrational probes.Nature methods · 2020Article
- Label-free, automated classification of microsatellite status in colorectal cancer by infrared imaging.Scientific reports · 2020Article
- All-digital histopathology by infrared-optical hybrid microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Advancement of discrete frequency infrared (DFIR) spectroscopic microscopes in image quality and data throughput are critical to their use for analytical measurements. Here, we report the development and characterization of a point scanning instrument with minimal aberrations and capable of diffraction-limited performance across all fingerprint region wavelengths over arbitrarily large samples. The performance of this system is compared to commercial state of the art Fourier transform infrared (FT-IR) imaging systems. We show that for large samples or smaller set of discrete frequencies, point scanning far exceeds (∼10-100 fold) comparable data acquired with FT-IR instruments. Further we show improvements in image quality using refractive lenses that show significantly improved contrast across the spatial frequency bandwidth. Finally, we introduce the ability to image two tunable frequencies simultaneously using a single detector by means of demodulation to further speed up data acquisition and reduce the impact of scattering. Together, the advancements provide significantly better spectral quality and spatial fidelity than current state of the art imaging systems while promising to make spectral scanning even faster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.