ReviewJournal of cellular physiology2019
Molecular mechanisms by which aerobic exercise induces insulin sensitivity.
Review in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Effects of Different Training Modalities on Circulating Irisin Levels in Overweight and Obesity Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- The crucial role and mechanism of insulin resistance in metabolic disease.Frontiers in endocrinology · 2023Pooled it
- Physical Exercise vs. Metformin to Improve Delivery- and Newborn-Related Outcomes Among Pregnant Women With Overweight: A Network Meta-Analysis.Frontiers in medicine · 2021Pooled it
- The effects of metformin and exercise training on cardiorespiratory, blood pressure, and metabolic adaptations across the spectrum of glucose dysregulation: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Mediating effect of health literacy on the relationship between diabetes status and aerobic physical activity adherence among middle-aged Korean adults: a theory-based secondary analysis of the second year of the ninth Korea National Health and Nutrition Examination Survey.Journal of Korean biological nursing science · 2026Article
- Reduced-exertion high-intensity interval training (REHIT) provides limited improvement in post-prandial and 24-hour glycemia in healthy, physically active men.Journal of exercise science and fitness · 2026Article
- Targeting Insulin Resistance Through Nutrition: Pathophysiological Insights and Dietary Interventions.Nutrients · 2026Review
- Assessment of Machine Learning Model Performance for Clinical Prediction of Insulin Resistance in the Study of Cardiovascular Risk in Adolescents-ERICA.Journal of clinical medicine · 2026Article
- Optimal exercise modalities for enhancing motor function recovery after stroke: a Bayesian systematic review with pairwise and network meta-analyses.EClinicalMedicine · 2026Article
- Aerobic training and cannabidiol activate the PI3K/AKT/PDX1 axis to ameliorate beta-cell dysfunction in a rat model of diet-induced obesity.Molecular biology reports · 2026Article
- [Aerobic exercise regulates macrophage polarization and improves insulin resistance in mice: the mediating role of miR-221-3p].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Effectiveness of Aerobic Exercise on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and GRADE Assessment of RCTs.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Age-Related Anabolic Resistance: Nutritional and Exercise Strategies, and Potential Relevance to Life-Long Exercisers.Nutrients · 2025Review
- Skeletal muscle and MASLD: Mechanistic and clinical insights.Hepatology communications · 2025Review
- Perspectives of physical activity in combating metabolic syndrome: insights from a multi-ethnic urban population.Frontiers in public health · 2025Article
- Aerobic exercise improves inflammation and insulin resistance in skeletal muscle by regulating miR-221-3p via JAK/STAT signaling pathway.Frontiers in physiology · 2025Article
- Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in the ADA/EASD consensus guidelines followed by metformin therapy. Aerobic exercise (AE) can increase insulin sensitivity by several molecular pathways including upregulation of insulin transporters in the cellular membrane of insulin-dependent cells. In addition, AE improves insulin sensitivity by amelioration of the pathophysiologic pathways involved in insulin resistance such as the reduction of adipokines, inflammatory and oxidative stress responses, and improvement of insulin signal transduction via different molecular pathways. This review details the molecular pathways by which AE induces beneficial effects on insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.