ReviewPersonality disorders2019
Personality and Alzheimer's disease: An integrative review.
Review in Personality disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analyses of personality change from the preclinical to the clinical stages of dementia.Ageing research reviews · 2025Pooled it
- Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- Effectiveness of Powerful Tools for Caregivers on Caregiver Burden and on Care Recipient Behavioral and Psychological Symptoms of Dementia: A Randomized Controlled Trial.Journal of the American Medical Directors Association · 2020Trial
- Premorbid Personality in Alzheimer's Disease and Caregiver Well-Being: The Role of Extraversion.Geriatrics (Basel, Switzerland) · 2026Article
- Personality moderates immunological and functional consequences of caregiver burden.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Psychometric Properties of a Neuropsychological Assessment Scale for Diagnosing Alzheimer's Disease in the Illiterate and Low-Educated Subjects in Iran.Iranian journal of psychiatry · 2025Article
- Personality traits and measures of neuropsychiatric symptoms.Aging & mental health · 2025Article
- Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID.BMC infectious diseases · 2024Article
- Personality and Transition From Mild Cognitive Impairment to Normal Cognition vs Dementia.Journal of the American Medical Directors Association · 2024Observational
- High-frequency assessment of mood, personality, and cognition in healthy younger, healthy older and adults with cognitive impairment.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- Personality traits moderate associations between word recall and subjective memory.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- Daily and Trait Personality Assessments' Relationship with Daily Experiences of Stress Risk and Resilience Factors.Journal of research in personality · 2024Article
- Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Are trajectories of personality and socioeconomic factors prospectively associated with midlife cognitive function? Findings from a 12-year longitudinal study of Mexican-origin adults.Psychology and aging · 2023Article
- Association of personality facets and cognition in the Lifelines population-based cohort study.Journal of psychiatric research · 2023Article
- Informant-rated change in personality traits, psychological distress, well-being, and social connection with dementia.Archives of gerontology and geriatrics · 2023Article
- Article
- Changes in Personality Before and During Cognitive Impairment.Journal of the American Medical Directors Association · 2023Observational
- Prediction of neuropathologic lesions from clinical data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The objective of this article is to review and integrate interrelated areas of research on personality and Alzheimer's disease (AD). Prospective studies indicate that individuals who score higher on conscientiousness (more responsible and self-disciplined) and lower on neuroticism (less anxious and vulnerable to stress) have a reduced risk of developing dementia, even in the presence of AD neuropathology. Personality is also related to measures of cognitive performance and cognitive decline, with effect sizes similar to those of other clinical, lifestyle, and behavioral risk factors. These associations are unlikely to be due to reverse causality: Long-term prospective data indicate that there are no changes in personality that are an early sign of the disease during the preclinical phase of AD. With the onset and progression of dementia, however, there are large changes in personality that are reported consistently by caregivers in retrospective studies and are consistent with the clinical criteria for the diagnosis of dementia. The review also discusses potential mechanisms of the observed associations and emphasizes the need for prospective studies to elucidate the interplay of personality traits with AD neuropathology (amyloid and tau biomarkers) in modulating the risk and timing of onset of clinical dementia. The article concludes with the implications of personality research for identifying those at greater risk of AD and the potential of personality-tailored interventions aimed at the prevention and treatment of AD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.