ArticleHuman brain mapping2019
Amyloid burden accelerates white matter degradation in cognitively normal elderly individuals.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis.BMC medicine · 2026Article
- Amyloid-beta statuses prediction with free water MR imaging features in Alzheimer's disease using machine learning models.BMC medical imaging · 2026Article
- Free Water Elevation in Alzheimer's Disease: Influence of Amyloid-Beta Deposition Beyond Brain Cell Loss.Journal of Korean medical science · 2026Article
- Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan.European journal of nuclear medicine and molecular imaging · 2025Article
- The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Heart-brain mapping: Cardiac atrial function is associated with distinct cerebral regions with high free water in older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- MRI free water mediates the association between water exchange rate across the blood brain barrier and executive function among older adults.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Free-water imaging reveals unique brain microstructural deficits in hispanic individuals with Dementia.Brain imaging and behavior · 2024Article
- Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging.Neurology · 2024Observational
- Assessment of Gray Matter Microstructural Alterations in Alzheimer's Disease by Free Water Imaging.Journal of Alzheimer's disease : JAD · 2024Article
- Intermittent fasting and Alzheimer's disease-Targeting ketone bodies as a potential strategy for brain energy rescue.Metabolic brain disease · 2024Review
- Associations between white matter integrity of the cingulum bundle, surrounding gray matter regions, and cognition across the dementia continuum.The Journal of comparative neurology · 2023Article
- Angiotensin II Receptor Blockers Reduce Tau/Aß42 Ratio: A Cerebrospinal Fluid Biomarkers' Case-Control Study.Pharmaceutics · 2023Article
- Tract-specific differences in white matter microstructure between young adultNeuroimage. Reports · 2022Article
- Searching for optimal machine learning model to classify mild cognitive impairment (MCI) subtypes using multimodal MRI data.Scientific reports · 2022Article
- MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- PET imaging of neural activity, β-amyloid, and tau in normal brain aging.European journal of nuclear medicine and molecular imaging · 2021Review
- Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- Article
- White matter microstructure disruption in early stage amyloid pathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
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Abstract
Alterations in parietal and temporal white matter microstructure derived from diffusion tensor imaging occur in preclinical and clinical Alzheimer's disease. Amyloid beta (Aβ) deposition and such white matter alterations are two pathological hallmarks of Alzheimer's disease. However, the relationship between these pathologies is not yet understood, partly since conventional diffusion MRI methods cannot distinguish between cellular and extracellular processes. Thus, we studied Aβ-associated longitudinal diffusion MRI changes in Aβ-positive (N = 21) and Aβ-negative (N = 51) cognitively normal elderly obtained from the Alzheimer's Disease Neuroimaging Initiative dataset using linear mixed models. Aβ-positivity was based on Alzheimer's Disease Neuroimaging Initiative amyloid-PET recommendations using a standardized uptake value ratio cut-off of 1.11. We used free-water imaging to distinguish cellular and extracellular changes. We found that Aβ-positive subjects had increased baseline right uncinate fasciculus free-water fraction (FW), associated with worse baseline Alzheimer's disease assessment scale scores. Furthermore, Aβ-positive subjects showed faster decrease in fractional anisotropy (FW-corrected) in the right uncinate fasciculus and faster age-dependent right inferior longitudinal fasciculus FW increases over time. Right inferior longitudinal fasciculus FW increases were associated with greater memory decline. Importantly, these results remained significant after controlling for gray and white matter volume and hippocampal volume. This is the first study to illustrate the influence of Aβ burden on early longitudinal (in addition to baseline) white matter changes in cognitively normal elderly individuals at-risk of Alzheimer's disease, thus underscoring the importance of longitudinal studies in assessing microstructural alterations in individuals at risk of Alzheimer's disease prior to symptoms onset.
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