Evidence map›Paper›PMID 30604766›Full record

SynthesisNature communications2019

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.

Andrew P Morris, Thu H Le, Haojia Wu, Artur Akbarov, Peter J van der Most, Gibran Hemani, George Davey Smith, Anubha Mahajan, Kyle J Gaulton, Girish N Nadkarni and 62 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 8 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 8 syntheses or guidelines pooled it, 156 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Guideline
  6. Pooled it
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  8. Pooled it
  9. Trial
  10. Article
  11. Article
  12. Article
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  14. Article
  15. SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

72 authors at 20 institutions in 10 countries.

Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK. apmorris@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-6805-6014
Thu H LeDepartment of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, 22908, USA.
Haojia WuDivision of Nephrology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Artur AkbarovDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PT, UK.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, Netherlands.ORCID http://orcid.org/0000-0001-8450-3518
Gibran HemaniMRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, BS8 1TH, UK.ORCID http://orcid.org/0000-0003-0920-1055
George Davey SmithMRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, BS8 1TH, UK.ORCID http://orcid.org/0000-0002-1407-8314
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0001-5585-3420
Kyle J GaultonDepartment of Pediatrics, University of California, San Diego, San Diego, CA, 92161, USA.
Girish N NadkarniCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Adan Valladares-SalgadoUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico.
Niels Wacher-RodarteUnidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico.
Josyf C MychaleckyjCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0003-2595-0005
Nicole D DuekerJohn P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33124, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Yang HaiInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
Gu ZhuGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK.
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Huddinge, 141 83, Sweden.
Susan H BlantonJohn P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33124, USA.
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, Netherlands.ORCID http://orcid.org/0000-0002-4127-8733
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Thomas A BuchananDepartment of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC, Los Angeles, CA, 90033, USA.
Sylvia CechovaDepartment of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, 22908, USA.
Fadi J CharcharSchool of Health and Life Sciences, Federation University Australia, Ballarat, VIC, 3350, Australia.ORCID http://orcid.org/0000-0002-6164-9941
Pei-Lun ChuDepartment of Internal Medicine, Fu Jen Catholic University Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, 242, Taiwan.
Jeffrey DammanDepartment of Pathology, Erasmus Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands.
James EalesDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PT, UK.ORCID http://orcid.org/0000-0001-6238-5952
Ali G GharaviDepartment of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0003-2801-233X
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, 751 85, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Andrew C HeathDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.
Eli IppDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Krzysztof KirylukDepartment of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Holly J KramerDepartment of Medicine and Nephrology, Loyola University Medical Center, Maywood, IL, 60153, USA.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Anders LarssonDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, 751 85, Sweden.
Cecilia M LindgrenWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Yingchang LuCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.
Grant W MontgomeryBrisbane Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID http://orcid.org/0000-0002-4140-8139
George J PapanicolaouEpidemiology Branch, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, Bethesda, MD, 20892, USA.
Leslie J RaffelDepartment of Pediatrics, Division of Genetic and Genomic Medicine, University of California, Irvine Orange, CA, 92868, USA.
Ralph L SaccoDepartments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Elena SanchezDepartment of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-7041-5485
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany.
Johan SundstromDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, 751 85, Sweden.ORCID http://orcid.org/0000-0003-2247-8454
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Anny H XiangDepartment of Research and Education, Kaiser Permanente Southern California, Pasadena, CA, 91101, USA.
Aleksandra ZivkovicInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany.
Lars LindDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, 751 85, Sweden.
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94309, USA.
Nicholas G MartinGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-4069-8020
John B WhitfieldGenetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Jianwen CaiCollaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7420, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Koichi MatsudaLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Tatjana RundekDepartments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Esteban J ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada.
Miguel CruzUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06720, Mexico.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, Groningen, Netherlands.
Maciej TomaszewskiDivision of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PT, UK.ORCID http://orcid.org/0000-0001-8215-6567
Benjamin D HumphreysDivision of Nephrology, Washington University School of Medicine, St Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-6420-8703
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516-8050, USA. noraf@unc.edu.
The Lundquist Institute · USUniversity of Miami · USUniversity of Virginia · USUppsala University · SEWashington University in St. Louis · USColumbia University · USIcahn School of Medicine at Mount Sinai · USMexican Social Security Institute · MXQIMR Berghofer Medical Research Institute · AURIKEN Center for Integrative Medical Sciences · JPUniversity Medical Center Groningen · NLCentre for Human Genetics · GBFred Hutch Cancer Center · USHeinrich Heine University Düsseldorf · DEUniversity of Bristol · GBUniversity of Manchester · GBUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USBroad Institute · USCardiovascular Institute of the South · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
The Genetic Determinants of Human GNRH DeficiencyP50HD028138 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SEMINARA, STEPHANIE BETH · 2014 to 2020
$12.9M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Genetics of IgA nephropathy by integrative network-based association studiesR01DK105124 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk · 2015 to 2026
$4.8M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
Genetics of kidney disease in diverse populationsR01DK117445 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2018 to 2022
$2.7M
Renal Mechanisms of Blood Pressure Regulation and Salt Sensitivity by CollectrinR01DK113632 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H. · 2017 to 2021
$1.8M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
APOL1, sickle cell trait and chronic kidney disease in African AmericansR56DK104806 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA, REINER, ALEXANDER P · 2016 to 2016
$300k
Trans-ethnic meta-analysis of blood pressure in African and European ancestriesR21HL123677 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2014 to 2015
$242k
British Heart Foundation PG/17/35/33001Medical Research Council MC_UU_00011/1NCATS NIH HHS UL1 TR002736NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NICHD NIH HHS P50 HD028138NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK105124NIDDK NIH HHS R01 DK113632NIDDK NIH HHS R01 DK117445NIDDK NIH HHS R56 DK104806NIEHS NIH HHS P30 ES010126NIH HHS S10 OD020069NIMHD NIH HHS R01 MD012765NINDS NIH HHS R37 NS029993Wellcome Trust 208806/Z/17/Z
6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. Fine-mapping reveals 40 high-confidence variants driving eGFR associations and highlights putative causal genes with cell-type specific expression in glomerulus, and in proximal and distal nephron. Mendelian randomisation supports causal effects of eGFR on overall and cause-specific CKD, kidney stone formation, diastolic blood pressure and hypertension. These results define novel molecular mechanisms and putative causal genes for eGFR, offering insight into clinical outcomes and routes to CKD treatment development.

Indexed as

AdultAgedBlood PressureEthnicityFemaleGenetic LociGenome-Wide Association StudyGlomerular Filtration RateHistone CodeHistonesHumansHypertensionKidneyKidney CalculiMaleMiddle AgedHistones

Identifiers

PMID30604766
PMCPMC6318312
OpenAlexW2907333597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.