ArticleNature communications2019
Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Trial
- Trial
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Distinct effects of current suicidal symptoms and lifetime suicide attempts on C-reactive protein levels and executive function in young people with major affective disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Bridging Species Differences in Rule Switching: How Humans and Monkeys Solve the Same Wisconsin Card Sorting Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors.npj aging · 2024Article
- Improving working memory by electrical stimulation and cross-frequency coupling.Molecular brain · 2024Article
- A Comparison of Rapid Rule-Learning Strategies in Humans and Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Same, Same but Different? A Multi-Method Review of the Processes Underlying Executive Control.Neuropsychology review · 2024Review
- Using predictive validity to compare associations between brain damage and behavior.Human brain mapping · 2023Article
- Mixtures of strategies underlie rodent behavior during reversal learning.PLoS computational biology · 2023Article
- Increase in cerebral microbleeds and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Increased cortical structural covariance correlates with anhedonia in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Risk Decision Making and Executive Function among Adolescents and Young Adults.Behavioral sciences (Basel, Switzerland) · 2023Article
- Proselfs depend more on model-based than model-free learning in a non-social probabilistic state-transition task.Scientific reports · 2023Article
- Comparing rapid rule-learning strategies in humans and monkeys.bioRxiv : the preprint server for biology · 2023Article
- Differential assessment of frontally-mediated behaviors between self- and informant-report in patients with obsessive-compulsive disorder following gamma ventral capsulotomy.Neuropsychologia · 2022Article
- Abstract task representations for inference and control.Trends in cognitive sciences · 2022Review
- Abnormal Prefrontal Functional Connectivity Is Associated with Inflexible Information Processing in Patients with Autism Spectrum Disorder (ASD): An fNIRS Study.Biomedicines · 2022Article
- Altered brain activity in the bilateral frontal cortices and neural correlation with cognitive impairment in schizophrenia.Brain imaging and behavior · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test. We applied computational modeling and voxel-based lesion-symptom mapping in 328 patients with focal lesions, to uncover cognitive processes and neural correlates of test scores. Our results reveal that lesions in the right prefrontal cortex are associated with elevated perseverative errors and reductions in the model parameter of sensitivity to punishment. These findings indicate that the capacity to flexibly switch between task sets requires the detection of contingency changes, which are enabled by a sensitivity to punishment that reduces perseverative errors. We demonstrate the power of model-based approaches in understanding patterns of deficits on classical neuropsychological tasks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.