ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2019
Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Sex Steroid Hormone Regulation of T-Cell Function and Antitumor Immunity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Review
- Review
- Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy.Seminars in immunopathology · 2025Review
- Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review).Molecular medicine reports · 2024Review
- Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation.Biochemistry and biophysics reports · 2024Article
- Unveiling sex-disparities and the impact of gender-affirming hormone therapy on periodontal health.Frontiers in dental medicine · 2024Review
- New insights on the potential effect of progesterone in Covid-19: Anti-inflammatory and immunosuppressive effects.Immunity, inflammation and disease · 2023Review
- Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells.Science immunology · 2023Article
- Regulatory T cells are paramount effectors in progesterone regulation of embryo implantation and fetal growth.JCI insight · 2023Article
- Progress on the Role of Estrogen and Progesterone Signaling in Mouse Embryo Implantation and Decidualization.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation.The Journal of steroid biochemistry and molecular biology · 2023Review
- Article
- The Role of Autophagy and Apoptosis in the Combined Action of Plasma-Treated Saline, Doxorubicin, and Medroxyprogesterone Acetate on K562 Myeloid Leukaemia Cells.International journal of molecular sciences · 2023Article
- Serum Metabolic Correlates of the Antibody Response in Subjects Receiving the Inactivated COVID-19 Vaccine.Vaccines · 2022Article
- Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception.Endocrinology · 2022Article
- Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone.Signal transduction and targeted therapy · 2022Article
- Importance of the endometrial immune environment in endometrial cancer and associated therapies.Frontiers in oncology · 2022Review
- Effects of sex steroids on thymic epithelium and thymocyte development.Frontiers in immunology · 2022Review
- Differential expression of nuclear hormone receptors by dendritic cell subsets in human vaginal mucosa and skin.Frontiers in immunology · 2022Article
- Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
problemSteroid hormones such as progesterone and glucocorticoids rise during pregnancy and are accountable for the adaptation of the maternal immune system to pregnancy. How steroid hormones induce fetal tolerance is not fully understood. We hypothesized that steroid hormones selectively regulate the T-cell response by promoting T-cell death. METHOD OF STUDY: We incubated murine spleen cells isolated from non-pregnant and pregnant mice with physiological concentrations of steroid hormones in vitro and analyzed T-cell subsets after 48 h of incubation. Results We found that progesterone and the synthetic glucocorticoid dexamethasone induce T-cell death. CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.