ArticleJournal of the American Society for Mass Spectrometry2019
A New Quantification Method Using Electrochemical Mass Spectrometry.
Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Absolute Quantitation of Phosphopeptides and Glycopeptides Using Coulometric Mass Spectrometry.ACS measurement science au · 2025Article
- Scanning Electrochemical Cell Microscopy for Sub-Micrometer Mass Spectrometric Studies of Electrochemical Reactions.ACS electrochemistry · 2025Article
- Article
- Standards-Free Absolute Quantitation of Oxidizable Glycopeptides by Coulometric Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024Article
- Absolute Quantitation of Peptides and Proteins by Coulometric Mass Spectrometry After Derivatization.International journal of mass spectrometry · 2024Article
- Standard-Free Absolute Quantitation of Antibody Deamidation Degradation and Host Cell Proteins by Coulometric Mass Spectrometry.Analytical chemistry · 2022Article
- Absolute Quantitation ofJournal of the American Society for Mass Spectrometry · 2022Article
- Absolute Quantitation of Tryptophan-Containing Peptides and Amyloid β-Peptide Fragments by Coulometric Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2021Article
- Calibration curve-free electrochemical quantitation by micro-nano multi-scale gap devices.Mikrochimica acta · 2021Article
- Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mass spectrometry-based quantification method has advanced rapidly. In general, the methods for accurate quantification rely on the use of authentic target compounds or isotope-labeled compounds as standards, which might be not available or difficult to synthesize. To tackle this grand challenge, this paper presents a novel approach, based on electrochemistry (EC) combined with mass spectrometry (MS). In this approach, a target compound is allowed to undergo electrochemical oxidation and then subject to MS analysis. The oxidation current recorded from electrochemistry (EC) measurement provides information about the amount of the oxidized analyte, based on the Faraday's Law. On the other hand, the oxidation reaction yield can be determined from the analyte MS signal changes upon electrolysis. Therefore, the total amount of analyte can be determined. In combination with liquid chromatography (LC), the method can be applicable to mixture analysis. The striking strength of such a method for quantitation is that neither standard compound nor calibration curve is required. Various analyte molecules such as dopamine, norepinephrine, and rutin as well as peptide glutathione in low quantity were successfully quantified using our method with the quantification error ranging from - 2.6 to + 4.6%. Analyte in a complicated matrix (e.g., uric acid in urine) was also accurately measured. Graphical Abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.