Evidence map›Paper›PMID 30604372›Full record

ArticleDigestive diseases and sciences2019

Intravenous Contrast-Enhanced Ultrasound for Assessing and Grading Postoperative Recurrence of Crohn's Disease.

María Jesús Martínez, Tomás Ripollés, Jose María Paredes, Eduardo Moreno-Osset, Juan Manuel Pazos, Esther Blanc

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Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn's Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Jesús MartínezDepartment of Radiology, Dr. Peset Universitary Hospital, 90 Gaspar Aguilar Avenue, 46007, Valencia, Spain. chusjmartinez@gmail.com.ORCID http://orcid.org/0000-0001-8142-5673
Tomás RipollésDepartment of Radiology, Dr. Peset Universitary Hospital, 90 Gaspar Aguilar Avenue, 46007, Valencia, Spain.
Jose María ParedesDepartment of Gastroenterology, Dr. Peset Universitary Hospital, Valencia, Spain.
Eduardo Moreno-OssetDepartment of Gastroenterology, Dr. Peset Universitary Hospital, Valencia, Spain.
Juan Manuel PazosDepartment of Radiology, Dr. Peset Universitary Hospital, 90 Gaspar Aguilar Avenue, 46007, Valencia, Spain.
Esther BlancDepartment of Radiology, Dr. Peset Universitary Hospital, 90 Gaspar Aguilar Avenue, 46007, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim was to investigate the contribution of contrast-enhanced ultrasound (CEUS) to improve the results of US in the evaluation of recurrence in postsurgical Crohn's disease (CD) and establish its role in the assessment of the severity.

methodsAnastomotic site was assessed in 108 postsurgical CD patients with B-mode, color Doppler and CEUS. Bowel wall thickness (WT), transmural complications or stenosis, color Doppler grade, and bowel wall contrast enhancement (BWCE)-using time-intensity curves-were correlated with endoscopic Rutgeerts score. A receiver operating characteristic (ROC) curve was built to establish the best cutoff to predict recurrence and the severity. A US scoring system was elaborated in order to determine the grade of recurrence.

resultsIleocolonoscopy detected recurrence in 90 (83.3%) subjects and severe recurrence in 62. WT ≥ 3 mm had an accuracy of 90.7% in the detection of endoscopic recurrence. The combination of parameters-WT ≥ 3 mm and BWCE (≥ 46%)-demonstrated similar accuracy (90.7%). A WT ≥ 5 mm showed the best specificity (100%) for the diagnosis of recurrence and a WT ≥ 6 mm the best specificity (95.7%) for the detection of severe recurrence. The combination of sonographic parameters-WT ≥ 6 mm or WT between 5 and 6 mm with BWCE ≥ 70%, or complications-obtained the best results grading the recurrence (sensitivity, specificity, and accuracy of 90.3%, 87%, and 88.9%, respectively).

conclusionsUS shows high sensitivity and specificity for the diagnosis of postsurgical recurrence. When combined with CEUS, it can improve the detection of severe recurrence.

Indexed as

Ultrasonography, Doppler, ColorAdministration, IntravenousAdolescentAdultAgedColonoscopyContrast MediaCrohn DiseaseFemaleHumansMaleMiddle AgedObserver VariationPhospholipidsPredictive Value of TestsProspective Studiescontrast agent BR1Contrast MediaPhospholipidsSulfur HexafluorideBowel sonographyContrast-enhanced ultrasoundCrohn’s diseasePostsurgical recurrence

Identifiers

PMID30604372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.